Aortic Geometry in Patients with Duplication 7q11.23 Compared to Healthy Controls

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Aortic Geometry in Patients with Duplication 7q11.23 Compared to Healthy Controls Kirstie M. Lechich1 · Yuri A. Zarate5,6 · Joshua A . Daily5,7 · R. Thomas Collins II1,2,3,4  Received: 4 January 2020 / Accepted: 22 May 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020

Abstract The aim of this study was to compare the size and geometry of the aorta in patients with 7q11.23 duplication (Dup7) to healthy controls. We retrospectively reviewed all echocardiograms in all patients with Dup7 evaluated at our institutions from June 2017 through September 2019. All standard aortic diameter measurements were made and recorded. Z-scores for the measurements were calculated. For comparison, a set of control echocardiograms was developed by randomly selecting 24 normal echocardiograms in age-matched patients who had undergone echocardiograms for an indication of either chest pain or syncope. In 58 echocardiograms from 21 Dup7 patients, all aortic measurements were increased compared to controls (p 

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