Apparent Solubility of Ibuprofen in Dimethyl Dodecyl Ammonium-Propane Sulfonate, DDAPS, Micelles, DDAPS/Butanol Mixtures
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Apparent Solubility of Ibuprofen in Dimethyl Dodecyl Ammonium-Propane Sulfonate, DDAPS, Micelles, DDAPS/Butanol Mixtures and in Oil-in-Water Microemulsions Stabilized by DDAPS Irfan Ullah • Musa Kaleem Baloch • Imran Ullah
Received: 20 May 2011 / Accepted: 11 August 2012 / Published online: 5 March 2013 Ó Springer Science+Business Media New York 2013
Abstract Solubility of drugs in aqueous media is a real issue for scientists and a lot of work is going on to resolve the issue. The same is the case for ibuprofen, which is a derivative of propionic acid, belongs to the NSAIDs family and has low solubility in pure water. Therefore, its solubility has been investigated in dimethyl dodecyl ammoniumpropane sulfonate, DDAPS, micellar solution, DDAPS/butanol mixtures and in various (hexane, decane and tetradecane) oil-in-water microemulsions to find out a suitable vehicle. The aggregation number, size and flow ability of micelles and microemulsions were estimated using refractive index, viscosity and light scattering measurements. It has been observed that these microemulsions have a higher ability to solubilize ibuprofen than DDAPS/butanol mixtures or DDAPS micelles. Keywords
Solubility Micelles Micro-emulsions Hydrocarbons oil NSAIDs
1 Introduction Ibuprofen belongs to the family of NSAIDs drugs and is a derivative of propionic acid. It is used for the relief of symptoms of arthritis, primary dysmenorrhea, fever, and as an analgesic, especially where there is an inflammatory component. However, its efficacy is limited due to its poor water solubility. A number of studies have been focused on increasing its solubility by using different media including surfactants [1–8]. Unfortunately, in the market one can hardly find an isotropic solution of surfactants and drugs [9]. In fact the use of surfactants for the solubilization of drugs is advantageous because in the micelles the reactivity of the drug may be different due to orientation and proximity of drug molecule with respect to water molecules. The dissolution of drugs into the micelles results in protection from the attack of hydrogen and hydroxyl ions [10]. The micellar I. Ullah (&) M. K. Baloch Department of Chemistry, Gomal University, Dera Ismail Khan 29050, Pakistan e-mail: [email protected] I. Ullah Agriculture Research Institute, Ratta Kulachi, Dera Ismail Khan 29050, Pakistan
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J Solution Chem (2013) 42:657–665
phase also enhances the transport properties of drugs and hence increases the bioavailability of the drug. However, the limited capacity of surfactant micelles for the solubilization of drugs reduces the application of surfactants for drug delivery. Another methodology for the solubilization of drug is in emulsions; this technology is very common and popular in skincare, cosmetics and pharmaceutical products but they are thermodynamically unstable and have large droplet sizes which limits its applications in drug delivery [11]. Microemulsions are most useful and interesting drug delivery systems because they are optically tran
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