Ibuprofen
- PDF / 169,738 Bytes
- 1 Pages / 595.245 x 841.846 pts (A4) Page_size
- 77 Downloads / 190 Views
1 S
Generalised bullous fixed-drug eruption: case report A woman in her 30s developed generalised bullous fixed drug-eruption (GBFDE) following treatment with ibuprofen for a common cold [route and dosage not stated]. The woman presented with erythematous lesions, which were present all over the trunk and extended towards the limbs. She had a significant history of generalised morphea for over 15 years. She had been receiving ibuprofen for a common cold. Erythematous lesions associated with pain on skin contact and slight itching appeared 24 hours after ibuprofen initiation. She had also developed lesions with similar characteristics located on the anterior thorax on two previous occasions during treatment with ibuprofen. Welldefined, partially confluent erythematous violaceous plaques located on the trunk and limbs were observed on physical examination. In addition, blisters were visible on the sacral regions. Test for the Nikolsky sign was positive. The woman was hospitalised with a provisional diagnosis of GBFDE and a prescription of ciclosporine, chlorphenamine and petroleum jelly. Skin biopsy revealed lichenoid dermatitis with superficial and deep perivascular epidermal necrosis which was lymphocytic, with eosinophils and melanophages. As it was compatible with an ADR, it confirmed the diagnosis of GBFDE. She showed an improvement in the symptoms associated with GBFDE after 5 days of treatment. She was discharged with a reduction in the dose of ciclosporine, which was discontinued 2 weeks after discharge. Vargas Mora P, et al. Generalized bullous fixed drug eruption successfully treated with cyclosporine. Dermatologic Therapy 33: e13492, No. 4, Jul 2020. Available from: 803504301 URL: http://doi.org/10.1111/dth.13492
0114-9954/20/1824-0001/$14.95 Adis © 2020 Springer Nature Switzerland AG. All rights reserved
Reactions 3 Oct 2020 No. 1824
Data Loading...
