Application of conductive poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) polymers in potential biom
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Journal of Pharmaceutical Investigation https://doi.org/10.1007/s40005-020-00485-w
REVIEW
Application of conductive poly(3,4‑ethylenedioxythiophene):poly (styrenesulfonate) (PEDOT:PSS) polymers in potential biomedical engineering Naznin Sultana1 · Hui Chung Chang1 · Sheryl Jefferson1 · Dennis E. Daniels1 Received: 24 October 2019 / Accepted: 15 April 2020 © The Korean Society of Pharmaceutical Sciences and Technology 2020
Abstract Background Biomedical engineering has emerged as a multidisciplinary endeavor. Biomedical engineering includes the development of new devices, processes, and systems in order to advance medical practice and health care. The specialty areas of biomedical engineering are biomaterials and tissue engineering (TE), bioinstrumentation, clinical and rehabilitation engineering. Area covered Over the past few decades, conductive polymers have received much attention in many applications. The applications of conductive polymers are in the drug delivery system, in the construction of bioactuators, as well as in the Tissue Engineering field. Composites are produced by combining conductive polymers with other polymers or materials. Modification of conductive polymers can render these polymers to be biodegradable and biocompatible, making them very useful in TE applications. Expert opinion Poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS), a biocompatible conductive polymer, is recently being researched, to be used as nano-bio interfaces for medical applications such as nucleic acid detection, controlled release of neuron growth factor, and guided cell growth. This review focuses on the recent advances of conductive polymers, specifically, PEDOT:PSS aiming towards TE, photovoltaic devices and biosensor applications. Keywords Tissue engineering · Conductive polymers · PEDOT:PSS · Biocompatible · Drug delivery
Introduction Conductive polymers with exceptional biocompatibility have been researched and used in various biomedical applications (Guimard et al. 2007). Currently, poly(3,4-ethylenedioxythiophene) (PEDOT) is used in various fields, including biomedicine and biotechnology due to its properties of high electrical conductivity and chemical stability (Ravichandran et al. 2010). PEDOT is doped with poly(4-styrenesulfonate) (PSS) in order to obtain a water-soluble polyelectrolyte system with good film-forming properties (Groenendaal et al. 2000). This copolymer has good stability and a moderate bandgap in the doping state (Schweizer 2005). Figure 1 shows the chemical structure of PEDOT:PSS. * Naznin Sultana [email protected] 1
Owing to its electrochemical, thermal, and oxidative stability, PEDOT:PSS had gained much attention from researchers. These properties allow PEDOT:PSS to be used in wide applications in areas of nanocomposites, flexible electrodes, electrochromic displays, transistors (Chen et al. 2002; Heuer et al. 2002; Daoud et al. 2005; Reddy et al. 2010). Also, because of its good oxidative stability, there has been an increased interest in PEDOT for biomedi
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