Application of intraoral scanner to identify monozygotic twins
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RESEARCH ARTICLE
Open Access
Application of intraoral scanner to identify monozygotic twins Botond Simon1* , Laura Lipták2, Klaudia Lipták2, Ádám Domonkos Tárnoki3,4, Dávid László Tárnoki3,4, Dóra Melicher4,5,6 and János Vág1
Abstract Background: DNA base identification is a proper and high specificity method. However, identification could be challenged in a situation where there is no database or the DNA sequence is almost identical, as in the case of monozygotic (MZ) twins. The aim of this study was to introduce a novel forensic method for distinguishing between almost identical MZ twins by means of an intraoral scanner using the 3D digital pattern of the human palate. Methods: The palatal area of 64 MZ twins and 33 same-sex dizygotic (DZ) twins (DZSS) and seven opposite-sex dizygotic twins (DZOS) were scanned three times with an intraoral scanner. From the scanned data, an STL file was created and exported into the GOM Inspect® inspection software. All scans within a twin pair were superimposed on each other. The average deviation between scans of the same subject (intra-subject deviation, ISD) and between scans of the two siblings within a twin pair (intra-twin deviation, ITD) was measured. One-sided tolerance interval covering 99% of the population with 99% confidence was calculated for the ISD (upper limit) and the ITD (lower limit). Results: The mean ISD of the palatal scan was 35.3 μm ± 0.78 μm. The calculated upper tolerance limit was 95 μm. The mean ITD of MZ twins (406 μm ± 15 μm) was significantly (p < 0.001) higher than the ISD, and it was significantly lower than the ITD of DZSS twins (594 μm ± 53 μm, p < 0.01) and the ITD of DZOS twins (853 μm ± 202 μm, p < 0.05). Conclusion: The reproducibility of palatal intraoral scans proved to be excellent. The morphology of the palate shows differences between members of MZ twins despite their almost identical DNA, indicating that this method could be useful in forensic odontology. Keywords: Palatal rugae, Intraoral scanner, Monozygotic twin, Forensic odontology, Human identification, Palate
Background DNA base identification is a proper, high specificity method in most situations [1]. However, identification could be challenged in a situation where there is no database, or the DNA sequence is almost identical, as in the case of monozygotic twins (MZ). There are * Correspondence: [email protected] 1 Department of Conservative Dentistry, Semmelweis University, Szentkirályi, utca 47, Budapest H-1088, Hungary Full list of author information is available at the end of the article
approximately 91.7 million twins in the world, and 28 million of them are monozygotic [2]. Identification of an MZ twin still poses obstacles in forensic science [3]. In addition to DNA-based identification, phenotypic differences could be recorded, such as by facial recognition. However, MZ twins resemble each other very much in most cases; therefore, it might be challenging to tell them apart [4]. Further identification methods include recording external features of the body
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