Applications of Electrochemistry and Nanotechnology in Biology and Medicine II
Topics in Number 53 include:·Fundamental studies of electron tunneling between electrodes and proteins·Electron transfer kinetics at oxide films on metallic biomaterials·How adsorption of organic molecules and ions depends on surface crystallography of th
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Series Editors: Ralph E. White Department of Chemical Engineering University of South Carolina Columbia, SC 29208 Constantinos G. Vayenas Department of Chemical Engineering University of Patras Patras 265 00 Greece Managing Editor: Maria E. Gamboa-Aldeco 1107 Raymer Lane Superior, CO 80027
For further volumes: http://www.springer.com/series/6251
Noam Eliaz Editor
Applications of Electrochemistry and Nanotechnology in Biology and Medicine II
Editor Noam Eliaz Faculty of Engineering School of Mechanical Engineering Tel-Aviv University Ramat Aviv Tel-Aviv 69978 Israel [email protected]
ISSN 0076-9924 ISBN 978-1-4614-2136-8 e-ISBN 978-1-4614-2137-5 DOI 10.1007/978-1-4614-2137-5 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011934050 © Springer Science+Business Media, LLC 2012 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identi¿ed as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface The emergence of nanoscience and nanotechnology has led to new developments in and applications of electrochemistry. These two volumes of Modern Aspects of Electrochemistry, entitled: “Applications of Electrochemistry and Nanotechnology in Biology and Medicine,” address both fundamental and practical aspects of several emerging key technologies. All Chapters were written by internationally renowned experts who are leaders in their area. The Chapter by A. Heiskanen and J. Emnéus provides a lucid and authoritative overview of electrochemical detection techniques for real-time monitoring of the dynamics of different cellular processes. First, biological phenomena such as the cellular redox environment, release of neurotransmitters and other signaling substances based on exocytosis, and cellular adhesion, are discussed thoroughly. Next, the capabilities of electrochemical amperometric and impedance spectroscopic techniques in monitoring cellular dynamics are highlighted, in comparison to optical and other techniques. The applications of such techniques already include biosensors and microchip-based biological systems for cell biological research, medical research and drug development. Finally, the state-of-the-art and future developments, e.g. miniaturization of planar interdigitated electrodes in order to achieve a gap/width size regime on the nanometer scale and thus considerable sig
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