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Dean Ho Editor

Nanodiamonds Applications in Biology and Nanoscale Medicine

Editor Dean Ho Northwestern University Evanston, IL USA [email protected]

ISBN 978-1-4419-0530-7 e-ISBN 978-1-4419-0531-4 DOI 10.1007/978-1-4419-0531-4 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2009933602 © Springer Science+Business Media, LLC 2010 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)

To my parents, Sarah, friends, family and colleagues for their inspiration and encouragement I would like to gratefully acknowledge my colleagues who have contributed to this book, as well as the National Science Foundation, National Institutes of Health, Wallace H. Coulter Foundation, V Foundation for Cancer Research, and Northwestern University, for supporting our work.

Preface

Nanodiamonds represent an emerging class of materials with important implications at the intersection of biology and medicine. Their consistent dimensions, unique surface properties, facile processing parameters and scalability, innate biocompatibility, and applicability as imaging/diagnostic and therapeutic platforms make them an ideal foundation for theranostic approaches. Their introduction to the field of nanomedicine couldn’t come at a more important time. The optimized monitoring and treatment of physiological disorders such as cancer and inflammation, as well as the addressing of key domains such as regenerative medicine necessitates the development of technologies such as nanodiamonds which can be engineered to meet the aforementioned as well as a spectrum of additional medical needs. A growing international community of researchers has convened towards the production of this book by sharing their multi-faceted strategies that have forged the role of nanodiamonds in impacting biology and medicine. As such, this book unites the expertise of pioneering efforts in the fundamental fabrication and characterization of nanodiamond particles and ultrananocrystalline diamond thin films, fluorescent nanodiamonds for biological labeling and cytotoxicity analysis, protein capture, and drug delivery particle and device design. Furthermore, the coalescence of nanodiamond platforms with technologies for cellular interrogation and nanomanufacturing are introduced to