Applying SF-6D to measure health state utilities among the middle and old aged patients with hypertension in China
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RESEARCH
Applying SF‑6D to measure health state utilities among the middle and old aged patients with hypertension in China Xiaohan Liu1,2, Guannan Bai3, Hui Li1,2* and Shunping Li1,2,4*
Abstract Purpose: Hypertension is a growing public health problem in China; however, little is known about health-related quality of life (HRQoL) especially health state utility (HSU) of patients with hypertension in rural China. This study aimed to examine the HSU as measured by SF-6D and to investigate its associated factors among middle and old aged patients with hypertension in rural China. Methods: Data were collected from twelve villages in Shandong Province in 2016. SF-36 was administrated to measure HRQoL of middle and old aged patients with hypertension and was got to the SF-6D values using Hong Kong’s tariff. Descriptive analyses, such as demographic characteristics, socio-economic status, and utility, were stratified by hypertension classification. Multiple linear regression models were applied to assess the associated factors of HSU. Results: A total of 933 (response rate:86.4%) middle and old aged patients (69.1 ± 8.2 years) with hypertension participated in the study. 39.4% of participants were male; 44.2% had stage I hypertension; 26.4% had stage II and above. The mean score of SF-6D utility score was 0.743 (SD: 0.14, range: 0.32–1.00, median: 0.756, Interquartile range:0.634– 0.859). Being female (β = −0.046), having two or more comorbidities (2 vs. 1 β = −0.066; > 3 vs. 1 β = −0.098) and the health expenditure higher than 2000 RMB (2000–3999 vs.< 2000 β = −0.042; 4000–5999 vs. 6000 vs. < 2000 β = −0.071) were significantly associated with lower SF-6D overall score; while being farmer (β = 0.032), having high household income (10,000–14,999 vs. < 5000 β = 0.045; > 15,000 vs. < 5000 β = 0.064) and having stage I and above hypertension (stage I vs. Normotensive β = 0.047; stage II vs. Normotensive β = 0.079; stage III vs. Normotensive β = 0.095) were significantly associated with higher SF-6D overall score. Conclusion: SF-6D was capable to measure quality of life middle and old aged patients with hypertension in China. And multiple factors were demonstrated to be significantly associated with quality of life. Keywords: Health utility, Hypertension, Preference-based measurement, Quality of life, SF-6D
*Correspondence: [email protected]; [email protected] 1 Centre for Health Management and Policy Research, School of Health Care Management, Cheeloo College of Medicine, Shandong University, Wenhua Xi Rd 44, Jinan 250012, Shandong Province, People’s Republic of China Full list of author information is available at the end of the article
Introduction Hypertension is the strongest risk factor of cardiovascular and cerebrovascular diseases as well as the related disabilities and mortality in worldwide [1]. About 80% of all cardiovascular mortality occurs in low-income and middle-income countries including China, where the greatest burden of hypertension has been observed [2]. A recent nation-wide surv
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