Aquaporins
The aquaporin field has matured at an exceptionally fast pace and we are at the verge to develop serious strategies to therapeutically modulate aquaporin function directly or via regulatory networks. Key prerequisites are available today: i. a considerabl
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Volume 190
Editor-in-Chief F. Hofmann, München Editorial Board J. Beavo, Seattle, WA A. Busch, Berlin D. Ganten, Berlin J.-A. Karlsson, Singapore M. Michel, Amsterdam C.P. Page, London W. Rosenthal, Berlin
Eric Beitz Editor
Aquaporins Contributors P. Agre, J.C. Atkinson, B. Baum, D. Becker, E. Beitz, S. Beulshausen, H. Bhattacharjee, F. Bonté, M. Boury-Jamot, J.S. Brahim, J.M. Carbrey, A. Chepelinsky, C. Conrad, A.P. Cotrim, J. Daraspe, B. de Groot, C. Delporte, M. Dumas, A. Engel, R.A. Fenton, S. Flitsch, N. Fricke, J. Frøkiær, Y. Fujiyoshi, T. Funahashi, A. Geadkaew, C.M. Goldsmith, H. Grubmüller, R. Haddoub, T. Hibuse, J.S. Hub, G.G. Illei, K. Ishibashi, E. Klussmann, D. Krenc, T.-H. Kwon, T. Litman, S. Liu, N. Maeda, G. Manley, L. McCullagh, H.B. Møller, R. Mukhopadhyay, P.I. Nedvetsky, J. Nielsen, S. Nielsen, N. Nikolov, E. Perrier, A. Robin, B.P. Rosen, W. Rosenthal, M. Rützler, S. Sasaki, S. Schnebert, R. Søgaard, E. Sohara, J. Song, S. Stiver, D. Taguchi, T. Takeda, G. Tamma, R.J. Turner, S. Uchida, G. Valenti, J.-M. Verbavatz, A.S. Verkman, J. von Bülow, T. Walz, V. Wang, D. Wree, B. Wu, M. Yasui, Z. Zador, T. Zeuthen, C. Zheng
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Editor Prof. Dr. Eric Beitz Universität Kiel Pharmazeutisches Inst. Gutenbergstr. 76 24118 Kiel Germany [email protected]
ISBN 978-3-540-79884-2
e-ISBN 978-3-540-79885-9
Handbook of Experimental Pharmacology ISSN 0171-2004 Library of Congress Control Number: 2008932921 c 2009 Springer-Verlag Berlin Heidelberg This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law.
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Preface
Sophisticated fluid regulation systems are in place in mammalian organism to maintain basic vital and sensory functions. Such systems control body water homeostasis on a large scale that requires daily filtration and reabsorption of 180 l of fluid from the blood. At the same time, the volume and ional composition of fluids in compartments as tiny as the 40 μl endolymphatic space of the sensory
