Articular cartilage repair using autologous collagen-induced chondrogenesis (ACIC): a pragmatic and cost-effective enhan
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KNEE
Articular cartilage repair using autologous collagen‑induced chondrogenesis (ACIC): a pragmatic and cost‑effective enhancement of a traditional technique Seok Jung Kim1 · Asode Ananthram Shetty2,3 · Nibu M. Kurian2,3 · Saif Ahmed2,3 · Neha Shetty2,3 · David Stelzeneder4 · Yong‑Woon Shin5 · Yoon Joo Cho1 · Sang Heon Lee1 Received: 20 August 2019 / Accepted: 23 January 2020 © European Society of Sports Traumatology, Knee Surgery, Arthroscopy (ESSKA) 2020
Abstract Purpose The autologous collagen-induced chondrogenesis technique is described, and the results of a 6-year follow-up clinical study using this technique are presented. Methods 30 patients with International Cartilage Repair Society (ICRS) Grade III/IVa symptomatic chondral defects of the knee treated with enhanced microdrilling using atelocollagen were prospectively examined in this clinical series. The median age of the patients was 39.0 years (range 19–61 years). Patients were followed up to 72 months. Clinical evaluation was performed using functional knee scores and radiologically. Both quantitative and qualitative assessments were performed. Results Statistically significant and clinically relevant improvement was observed in 2 years and was sustained for the 6 years of the study observation. At 6 years, the mean Lysholm score was 79.7 (SD 6.8) compared to 52.6 (SD 10.7) pre-operatively (p
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