Assessment of lung volume collapsibility in chronic obstructive lung disease patients using CT
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Assessment of lung volume collapsibility in chronic obstructive lung disease patients using CT Shinjini Kundu & Suicheng Gu & Joseph K. Leader & John R. Tedrow & Frank C. Sciurba & David Gur & Naftali Kaminski & Jiantao Pu
Received: 4 September 2012 / Revised: 14 November 2012 / Accepted: 25 November 2012 / Published online: 15 March 2013 # European Society of Radiology 2012
Abstract Objective To investigate the collapsibility of the lung and individual lobes in patients with COPD during inspiration/ expiration and assess the association of whole lung and lobar volume changes with pulmonary function tests (PFTs) and disease severity. Methods PFT measures used were RV/TLC%, FEV1% predicted, FVC, FEV1/FVC%, DLco% predicted and GOLD category. A total of 360 paired inspiratory and expiratory CT examinations acquired in 180 subjects were analysed. Automated computerised algorithms were used to compute individual lobe and total lung volumes. Lung volume collapsibility was assessed quantitatively using the simple difference between CT computed inspiration (I) and expiration (E) volumes (I-E), and a relative measure of volume changes, (I-E)/I. Results Mean absolute collapsibility (I-E) decreased in all lung lobes with increasing disease severity defined by GOLD classification. Relative collapsibility (I-E)/I showed a similar trend. Upper lobes had lower volume collapsibility across all GOLD categories and lower lobes collectively had the largest volume collapsibility. Whole lung and left lower lobe collapsibility measures tended to have the highest S. Gu : J. K. Leader : D. Gur : J. Pu
correlations with PFT measures. Collapsibility of lung lobes and whole lung was also negatively correlated with the degree of air trapping between expiration and inspiration, as measured by mean lung density. All measured associations were statistically significant (P
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