Assessment of the effects of autologous muscle-derived cell injections on urethral sphincter morphometry using 3D/4D ult
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ORIGINAL ARTICLE
Assessment of the effects of autologous muscle‑derived cell injections on urethral sphincter morphometry using 3D/4D ultrasound Salima Ismail1 · Mélanie Morin2 · Le Mai Tu1 Received: 22 August 2019 / Accepted: 2 January 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose The primary objective was to evaluate the effect of autologous muscle-derived cell (AMDC) injections on the urethral sphincter morphometry compared to placebo injections. Secondary aims were to explore the reduction of stress incontinence episode frequency (IEF) and factors associated with the efficacy of AMDC. Methods This prospective randomized-controlled study compared the urethral sphincter volumes of participants who had received either an intra-sphincteric injection of 4 cc AMDC in injection media or 4 cc placebo solution, using a transperineal 3D/4D ultrasound at baseline and at 12 months. The reduction of stress IEF on 3-day bladder diary and potential predictors at baseline for response to AMDC were assessed. Results Fifty-eight participants were included in the study. Compared to baseline, the mean total and external sphincter volumes increased significantly in both groups (respectively, p = 0.001 and p
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