Association Between Lipids, Lipoproteins Composition of HDL Particles and Triglyceride-Rich Lipoproteins, and LCAT and C
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ORIGINAL PAPER
Association Between Lipids, Lipoproteins Composition of HDL Particles and Triglyceride-Rich Lipoproteins, and LCAT and CETP Activity in Post-renal Transplant Patients El_zbieta Kimak • Jerzy Bylina • Janusz Solski • Magdalena Hałabis´ • Iwona Baranowicz-Ga˛szczyk Andrzej Ksia˛z_ ek
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The Author(s) 2013. This article is published with open access at Springerlink.com
Abstract High-density lipoprotein (HDL) remodeling within the plasma compartment and the association between lecithin-cholesterol acyltransferase (LCAT) and cholesterol ester transfer protein (CETP) activity, and lipid, lipoprotein concentrations and composition were investigated. The aim was to examine the high sensitivity of C-reactive protein (hsCRP), lipid, apolipoprotein B (apoB), apoAI, total apoAII, apoAIInonB, apoB-containing apoAII (apoB:AII), total apoCIII, apoCIIInonB, apoB-containing apoCIII (apoB:CIII) concentration and LCAT and CETP activity to gain an insight into the association between them and LCAT and CETP, 57 post-renal transplant (Tx) patients with and without statin therapy and in 15 healthy subjects. Tx patients had moderate hypertriglyceridemia, hypercholesterolemia, and dyslipoproteinemia, disturbed triglyceride-rich lipoproteins (TRLs) and HDL composition, decreased LCAT, and slightly increased hsCRP but no CETP activity. Spearman’s correlation test showed the association between lipids and lipoproteins and LCAT or CETP, and multiple ridge stepwise forward regression showed that immunosuppressive therapy in Tx patients can disturb HDL and TRLs composition. The results suggest that inhibition or activation of LCAT is due, in part, to HDL-associated lipoprotein. Lipoprotein composition of
E. Kimak (&)J. Solski M. Hałabis´ Department of Laboratory Diagnostics, Medical University, Lublin, Poland e-mail: [email protected] J. Bylina Department of Informatics and Statistics, Institute of Rural Health, Lublin, Poland I. Baranowicz-Ga˛szczykA. Ksia˛z_ ek Department of Nephrology, Medical University, Lublin, Poland
apoAI, apoAIInonB, and apoCIIInonB in HDL particle and apoB:AII TRLs can contribute to decrease LCAT mass in Tx patients. Tx patients without statin and with lower triglycerides but higher HDL cholesterol concentration and disturbed lipoprotein composition of ApoAI and apoAII in HDL particle can decrease LCAT, increase LDL cholesterol, aggravate renal graft, and accelerate atherosclerosis and chronic heart diseases. Keywords Apolipoprotein (apo)AI apoB apoAII apoAIInonB apoB-containing apoAII apoCIII apoCIIInonB apoB-containing apoCIII LCAT CETP hsCRP Renal transplant
Introduction Lecithin-cholesterol acyltransferase (LCAT) is a plasma enzyme that esterifies cholesterol and raises high-density lipoprotein cholesterol (HDL-C). Cholesteryl esters (CE) are significantly more hydrophobic than free cholesterol and are formed by LCAT partition from the surface of lipoprotein to the hydrophobic core. This transforms the small pre-b HDL into larger, spherical-shaped a-migrating forms of
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