Association between patient-reported outcomes and exercise test outcomes in patients with COPD before and after pulmonar
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(2020) 18:300
RESEARCH
Open Access
Association between patient-reported outcomes and exercise test outcomes in patients with COPD before and after pulmonary rehabilitation Roy Meys1,2* , Anouk A. F. Stoffels1,2,3, Sarah Houben-Wilke1, Daisy J. A. Janssen1,4, Chris Burtin5, Hieronymus W. H. van Hees3, Frits M. E. Franssen1,2, Bram van den Borst3, Emiel F. M. Wouters1,2, and Martijn A. Spruit1,2,5 on behalf of the BASES-consortium
Abstract Background: Over the years, the scope of outcomes assessment in chronic obstructive pulmonary disease (COPD) has broadened, allowing for the evaluation of various patient-reported outcomes (PROs). As it still remains unclear whether and to what extent PROs mirror the exercise performance of patients with COPD, the current study aimed to assess the association between different exercise test outcomes and PROs, before and after pulmonary rehabilitation (PR). Methods: Correlations between PROs used to describe health-related quality of life (HRQoL), mood status, level of care dependency and dyspnea in patients with COPD and commonly used laboratory- and field-based exercise test outcomes were evaluated in 518 individuals with COPD attending PR. Results: Overall, correlations between PROs and exercise test outcomes at baseline were statistically significant. The correlation between modified Medical Research Council (mMRC) dyspnea score and 6-min walking distance (6MWD) was strongest (ρ:-0.65; p
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