The association between cardiac injury and outcomes in hospitalized patients with COVID-19

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The association between cardiac injury and outcomes in hospitalized patients with COVID‑19 Shahrokh Karbalai Saleh1 · Alireza Oraii2 · Abbas Soleimani1 · Azar Hadadi3 · Zahra Shajari1 · Mahnaz Montazeri3 · Hedieh Moradi4 · Mohammad Talebpour5 · Azadeh Sadat Naseri1 · Pargol Balali2 · Mahsa Akhbari6 · Haleh Ashraf7,8 Received: 14 June 2020 / Accepted: 31 July 2020 © Società Italiana di Medicina Interna (SIMI) 2020

Abstract In this study, we aimed to assess the association between development of cardiac injury and short-term mortality as well as poor in-hospital outcomes in hospitalized patients with COVID-19. In this prospective, single-center study, we enrolled hospitalized patients with laboratory-confirmed COVID-19 and highly suspicious patients with compatible chest computed tomography features. Cardiac injury was defined as a rise of serum high sensitivity cardiac Troponin-I level above 99th percentile (men: > 26 ng/mL, women: > 11 ng/mL). A total of 386 hospitalized patients with COVID-19 were included. Cardiac injury was present among 115 (29.8%) of the study population. The development of cardiac injury was significantly associated with a higher in-hospital mortality rate compared to those with normal troponin levels (40.9% vs 11.1%, p value