Association between the baseline frailty and quality of life in patients with prostate cancer (FRAQ-PC study)
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ORIGINAL ARTICLE
Association between the baseline frailty and quality of life in patients with prostate cancer (FRAQ‑PC study) Tomoko Hamaya1 · Shingo Hatakeyama2 · Masaki Momota1 · Takuma Narita1 · Hiromichi Iwamura1 · Yuta Kojima1 · Itsuto Hamano1 · Naoki Fujita1 · Teppei Okamoto1 · Kyo Togashi1 · Tohru Yoneyama3 · Hayato Yamamoto1 · Takahiro Yoneyama3 · Yasuhiro Hashimoto1 · Chikara Ohyama1,2,3 Received: 5 August 2020 / Accepted: 28 September 2020 © Japan Society of Clinical Oncology 2020
Abstract Background The association between baseline frailty and health-related quality of life (HRQOL) in patients with prostate cancer (PC) remains unknown. Methods We retrospectively evaluated the association of pretreatment frailty with HRQOL in 409 patients with PC from February 2017 to April 2020. Frailty and HRQOL were evaluated using the geriatric 8 (G8) screening tool and QLQ-C30 questionnaire, respectively. The primary objective was comparison of G8 and QOL scores between the localized diseases (M0 group) and metastatic castration-sensitive PC (mCSPC group). Secondary objectives were to study the association of G8 and QOL scores in each group and effect of frailty (G8 ≤ 14) on worse QOL. Results The median age of patients was 70 years. There were 369 (surgery: 196, radiotherapy: 156, androgen deprivation therapy alone: 17) patients in the M0 and 40 patients in the mCSPC groups. There was a significant difference between the M0 and mCSPC groups in the G8 score (14.5 vs. 12.5), functioning QOL (94 vs. 87), global QOL (75 vs. 58), and 100–symptom QOL (94 vs. 85) scores. G8 scores were significantly associated with functioning, global, and 100–symptom QOL scores in both M0 and mCSPC groups. The multivariable logistic regression analyses showed that frailty (G8 ≤ 14) was significantly associated with worse global QOL, functioning QOL, and 100–symptom QOL scores. Conclusion The baseline frailty and HRQOL were significantly different between the localized and metastatic disease. The baseline frailty was significantly associated with worse HRQOL in patients with PC. Keywords Frailty · Geriatric 8 · Prostate cancer · Quality of life
Introduction Prostate cancer (PC) is the most frequent cancer among the men in Western countries and Japan [1–3]. Reflecting on the increasing population of elderly patients with PC, the interest in frailty in those patients has been increasing [4–6]. Frailty is a common syndrome in older adults that is theoretically defined as an aging-associated vulnerability and is related to an increased risk for poor health outcomes, such as hospitalization, health care resource utilization, and Electronic supplementary material The online version of this article (https://doi.org/10.1007/s10147-020-01798-4) contains supplementary material, which is available to authorized users. * Shingo Hatakeyama shingoh@hirosaki‑u.ac.jp Extended author information available on the last page of the article
mortality [7, 8]. Previous studies have demonstrated the utility of frailty on treatment selection (surge
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