Association Between TSLP Polymorphisms and Eczema in Japanese Women: the Kyushu Okinawa Maternal and Child Health Study
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Association Between TSLP Polymorphisms and Eczema in Japanese Women: the Kyushu Okinawa Maternal and Child Health Study Yoshihiro Miyake,1,4 Shinichi Hitsumoto,2 Keiko Tanaka,1 and Masashi Arakawa3
Abstract—We examined the association between thymic stromal lymphopoietin (TSLP) single nucleotide polymorphisms (SNPs) and eczema in young adult Japanese women. Cases were 188 women who met the criteria of the International Study of Asthma and Allergies in Childhood (ISAAC) for eczema. Controls were 565 women without eczema according to the ISAAC criteria, who had not been diagnosed with asthma, atopic eczema, and/or allergic rhinitis by a doctor and who had no asthma as defined by the European Community Respiratory Health Survey criteria and no rhinoconjunctivitis according to the ISAAC criteria. Compared with women with the TT genotype of SNP rs1837253, those with the TC or CC genotype had a significantly increased risk of eczema after adjustment for age and smoking, although this association was not significant in crude analysis. There were no relationships between SNP rs3806933 or rs2289276 and eczema. The TC and CC genotypes combined of SNP rs1837253 may be significantly positively associated with eczema. KEY WORDS: eczema; Japanese women; polymorphism; TSLP.
INTRODUCTION Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine expressed in the skin, gut, lungs, and thymus [1]. Several cellular targets of TSLP have been identified, including dendritic cells, lymphocytes, and granulocytes [2]. TSLP plays a critical role in Th2 cell differentiation [1, 2]. It is highly expressed in epithelial cells, especially keratinocytes from patients with atopic eczema [3]. The numbers of cells within the bronchial epithelium and submucosa expressing mRNA for TSLP are significantly increased in asthmatics as compared with control subjects, and TSLP expression is correlated with airway obstruction [4]. The human TSLP gene is located on chromosome 5q22.1, near the atopic cytokine cluster on 5q31. Several 1
Department of Public Health, Ehime University Graduate School of Medicine, 791-0295 Ehime, Japan 2 Total Medical Support Center, Ehime University Hospital, Ehime, Japan 3 Health Tourism Research Center, Graduate School of Tourism Sciences, University of the Ryukyus, Okinawa, Japan 4 To whom correspondence should be addressed at Department of Public Health, Ehime University Graduate School of Medicine, 7910295 Ehime, Japan. E-mail: [email protected]
genetic association studies have examined the relationships between the TSLP single-nucleotide polymorphisms (SNPs) and allergic disorders, but the results have been inconsistent [5–12]. To our knowledge, only one study has investigated the association between TSLP SNPs and eczema [11], and only one other study has assessed the interactions between TSLP SNPs and smoking with respect to asthma [8]. In view of the lack of epidemiological information regarding the association between TSLP SNPs and eczema in non-Western populations, the current case-co
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