Association of adipocytokines with lipid and glycemic profiles in women with normal weight obesity
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RESEARCH ARTICLE
Open Access
Association of adipocytokines with lipid and glycemic profiles in women with normal weight obesity Ehsaneh Taheri1*, Saeed Hosseini2, Mostafa Qorbani3 and Parvin Mirmiran4*
Abstract Background: Individuals with normal weight obesity (NWO) are predisposed to having cardiometabolic disorders. This study aims to investigate the circulating levels of vaspin, leptin and their association with glycemic and lipid profiles in women with NWO. Methods: Forty women with body mass index (BMI) = 18.5–24.9 kg/m2 and fat mass (FM) ≥ 30% were assigned in the NWO group. Thirty age-matched women with identical BMI range, and FM < 30% (normal weight non-obese; NWNO) were considered as a control group. In addition to anthropometric measurements, glycemic and lipid profiles and circulating levels of leptin and vaspin were measured. Results: The mean ± standard deviation (SD) age of participants was 28.76 ± 4.76 years in the NWO group and 29.23 ± 4.50 years in the control group. The NWO group had the higher mean serum levels of insulin (9.02 ± 4.75 vs. 6.24 ± 2.51, P = 0.009), leptin (17.31 ± 8.10 vs. 9.94 ± 4.30, P < 0.001) and homeostatic model assessment of insulin resistance (HOMA-IR) (33.77 ± 20.71 vs. 23.48 ± 10.03, P = 0.009) compared to the NWNO group. The serum level of vaspin was higher in the NWO group compared to the control group (34.82 pg/ml vs. 27.72 pg/ml, respectively, P = 0.12). In NWO group, the serum levels of leptin had positive correlation with FBS (r = 0.45, P = 0.02), insulin (r = 0.51, P = 0.008), and HOMA-IR (r = 0.46, P = 0.02) and vaspin concentration was associated with insulin (r = 0.36, P = 0.02) and HOMA-IR (r = 0.30, P = 0.06), positively. Conclusion: It is concluded that the concentration of insulin and HOMA-IR index were significantly higher in women with NWO compared to NWNO. Higher concentrations of leptin and vaspin in the NWO group were associated with glycemic profile. Keywords: Normal weight obesity, Adipokines, Glycemic profile, lipid profile
Background Overweight and obesity, as a major public health concern, have become a global epidemic [1]. Obesity, as excess body fat accumulation, is a major risk factor for * Correspondence: [email protected]; [email protected] 1 Student Research Committee, Shahid Beheshti University of Medical Sciences, Arabi Ave, Daneshjoo Blvd, Velenjak, Tehran 19839-63113, Iran 4 Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran Full list of author information is available at the end of the article
many chronic diseases such as metabolic syndrome, dyslipidemia, hypertension, infertility, diabetes mellitus as well as cancer and cardiometabolic diseases [2]. Obesity is defined as body mass index (BMI) ≥ 30 kg/ m2 in practical and research medicine. In addition to BMI, other anthropometric indices such as waist circumference (WC) and waist to hip ratio (WHR) were used to determine abdominal obesity. Despite the wide
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