Association of apolipoprotein A5 genetic polymorphisms with steroid-induced osteonecrosis of femoral head in a Chinese H
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RESEARCH
Open Access
Association of apolipoprotein A5 genetic polymorphisms with steroid-induced osteonecrosis of femoral head in a Chinese Han population Yong Cui, Aihemaiti Kaisaierjiang, Peng Cao, Zhong-Yan Wu* and Qing Lv
Abstract Background: Previous studies suggested that apolipoprotein A5 (ApoA5) genetic polymorphisms (SNPs) may result in lipid metabolism disorders. Therefore, genetic polymorphisms in ApoA5 may be associated with the occurrence of osteonecrosis of femoral head (ONFH). Methods: We designed a case? control study including 223 patients of osteonecrosis and 201 age- and sex-matched control subjects to analyze the association between ApoA5 polymorphisms and susceptibility of steroid-induced ONFH. We utilized polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method to genotype two SNPs (rs662799 and rs3135506) in ApoA5 gene. Results: We found both rs662799 and rs3135506 were associated with the risk of ONFH in codominant, dominant, and recessive model, respectively. Haplotype analyses suggested that T-C haplotype was associated with decreased risk of ONFH, whereas the haplotype C-C was significantly associated with an increased risk of ONFH. Conclusion: Our study suggested that ApoA5 genetic polymorphisms were associated with susceptibility to ONFH in Chinese population. However, our results need further investigation with large sample size and various populations. Virtual Slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/ 13000_2014_229 Keywords: Apolipoprotein A5, Steroid-induced osteonecrosis, Gene polymorphism
Background Osteonecrosis of femoral head (ONFH) is a kind of orthopedic refractory disease that cellular death happens within femoral head owing to damage of blood supply to the anterior-superior-lateral part of the femoral head [1]. In China, there are approximately 7 million people with ONFH currently. And, new cases reached to 100? 200 thousand each year [2]. ONFH is a complex disorder may result from various risk factors such as trauma, alcoholism, coagulation defects, and abnormal lipid metabolism. Recent study suggested that abnormal lipid metabolism is main pathogenesis of osteonecrosis [3]. Hyperlipidemia affects the microcirculation of the femoral head to result in femoral necrosis from multiple links, such as affecting blood coagulation solvent systems, influencing bone fat * Correspondence: [email protected] Department of orthopetics, Fifth Affiliated Hospital of Xinjiang Medical University, No.118, Henan West Street, Urumqi 830011, China
embolism, and affecting the formation of bone microthrombosis [4,5]. ApoA5 is an important apolipoprotein which involved in plasma lipid metabolism. The most significant impact on plasma triglycerides (TG) levels seems to be associated with ApoA5 gene (ID 116519, OMIM accession number 606368) variants [6,7]. ApoA5 is located on TG-rich and high density lipoprotein (HDL) particles, enhances the activity of lipoprotein lipase [7,8], and recombinant
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