Association of neutrophil-to-lymphocyte ratio and risk of cardiovascular or all-cause mortality in chronic kidney diseas
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ORIGINAL ARTICLE
Association of neutrophil‑to‑lymphocyte ratio and risk of cardiovascular or all‑cause mortality in chronic kidney disease: a meta‑analysis Guangyu Ao1 · Yushu Wang2 · Xin Qi3 · Fengping Wang4 · Huitao Wen1 Received: 29 April 2020 / Accepted: 17 September 2020 © Japanese Society of Nephrology 2020
Abstract Background It is currently controversial whether neutrophil-to-lymphocyte ratio (NLR) has a prognostic role in patients with chronic kidney disease (CKD). We aimed to investigate whether NLR was an independent predictor of cardiovascular or all-cause mortality in CKD patients with or without hemodialysis by performing a meta-analysis. Methods Pubmed, Embase, and Cochrane Library databases are systematically searched for relevant literature that investigated NLR and subsequent cardiovascular or all-cause mortality risk in CKD with or without dialysis. Pooled hazard risk (HR) with 95% confidence interval (CI) was calculated for the high vs. low NLR category. Results A total of thirteen studies enrolling 116,709 patients were identified and analyzed. In summary, high NLR was associated with an increased risk of all-cause mortality (HR 1.93, 95% CI 1.87–2.00; P
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