J-shaped association of platelet-to-lymphocyte ratio with 5-year mortality among patients with chronic kidney disease in
- PDF / 840,920 Bytes
- 15 Pages / 595.276 x 790.866 pts Page_size
- 80 Downloads / 289 Views
NEPHROLOGY - ORIGINAL PAPER
J‑shaped association of platelet‑to‑lymphocyte ratio with 5‑year mortality among patients with chronic kidney disease in a prospective cohort study Mengru Zeng1 · Yu Liu1 · Fuyou Liu1 · Youming Peng1 · Lin Sun1 · Li Xiao1 Received: 11 April 2020 / Accepted: 17 June 2020 © Springer Nature B.V. 2020
Abstract Purpose To examine whether platelet-to-lymphocyte ratio (PLR) is associated with 5-year mortality in patients with chronic kidney disease (CKD), we performed this study using data from the National Health and Nutrition Examination Survey (NHANES) through 1999 to 2006. Methods 3285 patients with CKD stage 1–5 were included. Patients’ baseline characteristics were collected. Cox proportional hazards models were used to investigate the association of PLR with 5-year mortality including all-cause and cardiovascular mortality. Subgroup analysis was performed. Results Within 5 years following the date of the NHANES 1999 to 2006 survey participation, 655 (19.94%) deaths were recorded and 207 patients died from cardiovascular disease. A J-shaped association between PLR and 5-year mortality was observed. In adjusted model 2, the elevated PLR Z-score was not significantly associated with a decreased 5-year all-cause mortality risk (HR: 0.44, 95% CI: 0.16–1.22) when PLR Z-score
Data Loading...
