Asymptomatic Atherosclerosis Pathophysiology, Detection and Treatmen

Despite recent advances in the diagnosis and treatment of symptomatic atherosclerosis, available traditional screening methods for early detection and treatment of asymptomatic coronary artery disease are grossly insufficient and fail to identify the majo

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Asymptomatic Atherosclerosis Pathophysiology, Detection and Treatment Edited by

Morteza Naghavi, MD

Society for Heart Attack Prevention and Eradication (SHAPE) Houston, Texas USA

Editor Morteza Naghavi, MD Society for Heart Attack Prevention and Eradication (SHAPE) 710 North Post Oak, Suite 400 Houston, Texas 77024 [email protected]

ISBN 978-1-60327-178-3 e-ISBN 978-1-60327-179-0 DOI 10.1007/978-1-60327-179-0 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2009930357 © Springer Science+Business Media, LLC 2010 All rights reserved. This work may not be translated or copied in whole or in part without the written ­permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or ­scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, ­computer software, or by similar or dissimilar or medical dissimilar methodology now known or hereafter developed is ­forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)

Dedications and Acknowledgments

They say that dedicating a book is one of the most exquisite acts of love and generosity one can perform. I would agree, and would like to dedicate my efforts in realizing this book to the following: To my father, Mohsen Naghavi, who grew up in a hardworking farmer family with 13 children who were fighting poverty and did not have the luxury of going to school. Nonetheless, he always inspired his children with stories of successful people and encouraged them to have great ambitions. He lived a difficult life as a bus driver, but brought up his 7 children to be thriving doctors, engineers, and teachers. To my mother, Khadijeh Naghavi, whose countless sacrifices and never-ending patience have kept our family warm with love. To my first mentors, Drs S. Ward Casscells and James T. Willerson, whose integrity and ingenuity taught me priceless lessons and enabled me to realize my “American Dream”. To my respectful advisors, Drs P.K. Shah and Valentin Fuster whose generous support further helped me establish my career. To my academic colleagues, Drs Erling Falk, Harvey Hecht, Mathew Budoff, Craig Hartley, Ralph Metcalfe, and Ioannis Kakadiaris for their friendship, trust a