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Damage-Associated Molecular Patterns in Human Diseases

Walter Gottlieb Land

Damage-Associated Molecular Patterns in Human Diseases Volume 2: Danger Signals as Diagnostics, Prognostics, and Therapeutic Targets

Walter Gottlieb Land Laboratoire d’ImmunoRhumatologie Moléculaire LabEx TRANSPLANTEX Université de Strasbourg Strasbourg France German Academy for Transplantation Medicine Munich Germany

ISBN 978-3-030-53867-5    ISBN 978-3-030-53868-2 (eBook) https://doi.org/10.1007/978-3-030-53868-2 © Springer Nature Switzerland AG 2020 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland

Foreword

The Munich SOD Trial: A Few Anecdotes When searching for the scientific origin and foundation of this book on Damage-­ Associated Molecular Patterns in Human Diseases, one inevitably comes across a clinical study that we conducted in the late 1980s/early 1990s on kidney transplant patients and published in 1994: The Munich superoxide dismutase (SOD) trial [1]. I remember several anecdotal but remarkable stories around this trial that has led to the development of the Injury Hypothesis in Immunology [2–5]. Of interest, for example, is the launching phase of the clinical trial that started in 1986. The first step in initiating this trial came from me, who, at that time, was the Chairman of the Department of Experimental Surgery at the University of Heidelberg, Germany. In the late 1960s and early 1970s, I worked with Walter Land at the Institute of Surgical Research in Munich under Professor Walter Brendel, and we knew each other very well. In Heidelberg, one of the main topics of research was microcirculatory changes in ischemia/reperfusion injury in hamsters and hairless mice. Together with Karl A