Atrial Fibrillation, a Treatable Disease?
The attack of atrial fibrillation experienced by President Bush of the United States attracted more attention from the general public to atrial fibrillation than ever before. Also, there is a growing body of knowledge of the pathophysiologic mechanism, th
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J. H. Kingma N. M. van Hemel Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands
and
K.1. Lie Department ofCardiology, Thorax-center, University Hospital Groningen, Groningen, The Netherlands
Springer Science+Business Media, B.V.
ISBN 978-94-010-4801-9 ISBN 978-94-011-1816-3 (eBook) DOI 10.1007/978-94-011-1816-3
Printed on acid-free paper
AII Rights Reserved 1992 Springer Science+Business Media Dordrecht Originally published by Kluwer Academic Publishers in 1992 No part of the material protected by this copyright notice may be reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording or by any information storage and retrieval system, without written permission from the copyright owner.
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Developments in Cardiovascular Medicine VOLUME 139
The titles published in this series are listed at the end of this volume.
ATRIAL FIBRll..LATION, A TREATABLE DISEASE?
CONTENTS
Foreword
Philippe Coumel
xi
Preface
J. Herre Kingma, Norbert M. van Hemel, Kong I. Lie
xv
Acknowledgements
xix
SECTION 1: Concepts and Clinics of Atrial Fibrillation Chapter 1
From Experiment to Therapeutic Innovation in Atrial Fibrillation and Flutter. Norbert M. van Hemel, Jacques M. T. de Bakker, Anand Ramdat Misier, Jo A.M. Defauw.
Introduction 2 The sinus node in atrial fibrillation 2 Refractory periods and atrial fibrillation 4 A theory to explain the different conversion rate of atrial 8 fibrillation and flutter after Class Ic antiarrhythmics Nonpharrnacologic treatment of atrial flutter 10 Nonpharmacologic treatment of atrial fibrillation 12 Concluding remarks 19
Chapter 2
Atrial Functional Anatomy.
23
Gerard M. Guiraudon, Colette M. Guiraudon.
Introduction 24 Gross anatomy 24 Functional anatomy 36 Hemodynamic function 36 Comments 39
Chapter 3
The Pathology of Drug Resistant Lone Atrial Fibrillation in Eleven Surgically Treated Patients. Colette M. Guiraudon, Nicolette M. Ernst, Gerard M. Guiraudon, Raymond Yee, George J. Klein.
Introduction 42 Material and Methods Results 44 Comments 53 Discussion 54 56 Conclusion
42
41
vi
Chapter 4
Termination of Atrial Fibrillation by Class Ic Antiarrhythmic Drugs, a Paradox?
Maurits A. Allessie, Charles Kirchhof.
Pathophysiologic mechanisms of atrial fibrillation The wavelength concept 61 The substrate of atrial fibrillation 62 The antifibrillatory action of Class Ic drugs 63
Chapter 5
59
60
Characteristics of Patients with Chronic Atrial Fibrillation and the Prediction of Successful DC Electrical Cardioversion.
67
Isabelle C. van Gelder, Harry J.G.M. Crijns, Kong I. Lie.
Introduction 68 Characteristics of patients with chronic atrial fibrillation 69 Therapeutic strategy of chronic atrial fibrillation 72 Direct current electrical cardioversion 72 Immediate outcome of DC electrical cardioversion 75 Complications 79 Summary and guideline 82
SECTION 2: Recent Advances in the Treatment of Paroxysmal Atrial Fibrillation and Flutter Chapter 6
Pharmacological Cardioversion of Paroxysmal Atr
