Autologous mesenchymal stem cells application in post-burn scars treatment: a preliminary study
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Autologous mesenchymal stem cells application in post-burn scars treatment: a preliminary study Peter Zahorec . Nina Sarkozyova . Nikola Ferancikova . Peter Bukovcan . Lubos Danisovic . Martin Bohac . Miroslav Tomas . Jan Koller
Received: 18 February 2020 / Accepted: 26 August 2020 Ó Springer Nature B.V. 2020
Abstract Mesenchymal stem cells (MSCs) are multi-potent cells characterized by long term selfrenewal and by potential for differentiation into cells of different mesenchymal tissue types such as fibroblasts, osteocytes, chondrocytes, and adipocytes. Their unique properties offer broad therapeutic potentials. Bone marrow has been used as the most common MSCs source, but it is gradually going to be replaced by adipose tissue which showed to contain more MSCs per unit than the bone marrow and clinical application of MSCs procured from the adipose tissue have been
P. Zahorec (&) N. Sarkozyova N. Ferancikova P. Bukovcan J. Koller Department of Burns and Reconstructive Surgery, Faculty of Medicine, Comenius University, University Hospital, Pazitkova 4, 821 01 Bratislava, Slovakia e-mail: [email protected] L. Danisovic Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University in Bratislava, Sasinkova 4, 811 08 Bratislava, Slovakia M. Bohac Department of Plastic, Reconstructive and Aesthetic Surgery, Faculty of Medicine, Comenius University in Bratislava, University Hospital, Pazitkova 4, 821 01 Bratislava, Slovakia M. Tomas Department of Surgical Oncology, National Cancer Institute Bratislava, Klenova´ 1, 833 10 Bratislava, Slovakia
demonstrating at least similar results. Post-burn scars result frequently in severe both functional and aesthetic impairments in restitution and rehabilitation periods of the burn disease. Despite extensive research in the last decades, the exact mechanisms of scar formation remains unclear. The development of postburn scars is influenced by multiple factors such as initial depth of the burn, methods of burn wound therapy, duration of the open wound until final wound closure, burn wound infection, genetic predisposition, and many others in both acute and rehabilitation periods. The aim of this study was to point out versatility of the implementation of this method with respect to different types of scars (atrophic scars, hypertrophic scars, keloids). Autologous adipose tissue derived MSCs were applied to post-burn scars in all 8 patients undergoing surgical scar reconstructions at the Department of Burns and Reconstructive Surgery of the University Hospital in Bratislava. The study was approved by Ethical Committee of Ruzinov Hospital. The procedures used for scar reconstructions included dermabrasion, scar excisions, contractures corrections and local plasties combined by lipografting of lipoaspirate containing parenchymal adipocytes and stromal vascular fraction including MSCs, or application of separated autologous MSCs isolated from lipoaspirates. Based on desired result one of th
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