Autonomic symptoms, cardiovascular and sudomotor evaluation in de novo type 1 narcolepsy
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RESEARCH ARTICLE
Autonomic symptoms, cardiovascular and sudomotor evaluation in de novo type 1 narcolepsy Camilla Rocchi1 · Fabio Placidi2 · Chiara Del Bianco2 · Claudio Liguori2 · Antonio Pisani2 · Nicola B Mercuri1 · Francesca Izzi2 Received: 10 June 2020 / Accepted: 6 August 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose To evaluate cardiovascular and sudomotor function during wakefulness and to assess autonomic symptoms in de novo patients with type 1 narcolepsy compared to healthy controls. Methods De novo patients with type 1 narcolepsy (NT1) and healthy controls underwent cardiovascular function tests including head-up tilt test, Valsalva maneuver, deep breathing, hand grip, and cold face, and sudomotor function was assessed through Sudoscan. Autonomic symptoms were investigated using the Scales for Outcomes in Parkinson’s Disease–Autonomic Dysfunction (SCOPA-AUT) questionnaire. Results Twelve de novo patients with NT1 and 14 healthy controls were included. In supine rest condition and at 3 min and 10 min head-up tilt test, the systolic blood pressure values were significantly higher in the NT1 group than in controls (p
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