Autophagy at the Cell, Tissue and Organismal Level
This book provides an expert summary of autophagy, a relatively new but rapidly expanding field of biomedical science with important implications in health and disease. After a historical review ranging up to the identification of autophagy genes in mamma
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Eleftherios Karanasios Nicholas T. Ktistakis
Autophagy at the Cell, Tissue and Organismal Level
123
SpringerBriefs in Cell Biology
More information about this series at http://www.springer.com/series/10708
Eleftherios Karanasios Nicholas T. Ktistakis •
Autophagy at the Cell, Tissue and Organismal Level
123
Nicholas T. Ktistakis Babraham Institute Babraham, Cambridge UK
Eleftherios Karanasios Babraham Institute Babraham, Cambridge UK
SpringerBriefs in Cell Biology ISBN 978-3-319-33143-0 DOI 10.1007/978-3-319-33145-4
ISBN 978-3-319-33145-4
(eBook)
Library of Congress Control Number: 2016937510 © The Author(s) 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG Switzerland
Contents
1 Autophagy (Autophagia) from 1860 to 1963 . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 History of Autophagy After 1963 . . . . . . . . . . . . . . . . . . . . . . . 2.1 The First Morphological Studies . . . . . . . . . . . . . . . . . . . . 2.2 The First Functional Studies . . . . . . . . . . . . . . . . . . . . . . . 2.3 Difficulties in the Study of Autophagy . . . . . . . . . . . . . . . . 2.4 Molecular Era—Identification of Autophagy Genes in Yeast . 2.5 Identification of Autophagy Genes in Mammals. . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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3 Signalling in Autophagy. . . . . . . . . . . . . . . . . . . . . . . . . 3.1 Basal Versus Induced Autophagy. . . . . . . . . . . . . . . 3.2 Provenance of Autophagy Signals and Their Function 3.3 mTORC1 is the Major Signalling Hub for Autophagy Regulation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3.4 Signalling via AMPK . . . . . . . . . . . . . . . . . . . . . .
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