Autophagy Networks in Inflammation
Autophagy principally serves an adaptive function to protect organisms against diverse human pathologies, including cancer and neurodegeneration. Recent developments using in vitro, ex vivo and in vivo models show the involvement of the autophagy pathway
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Maria Chiara Maiuri Daniela De Stefano Editors
Autophagy Networks in Inflammation
Progress in Inflammation Research
Series Editors Michael J. Parnham Fraunhofer IME & Goethe University Frankfurt, Germany Achim Schmidtko Goethe University Frankfurt, Germany
More information about this series at http://www.springer.com/series/4983
Maria Chiara Maiuri • Daniela De Stefano Editors
Autophagy Networks in Inflammation
Editors Maria Chiara Maiuri Centre de Recherche des Cordeliers UMRS 1138 – Team 11 Paris France
Daniela De Stefano Multi Medica Fondazione Onlus Milan Italy
Progress in Inflammation Research ISBN 978-3-319-30077-1 ISBN 978-3-319-30079-5 DOI 10.1007/978-3-319-30079-5
(eBook)
Library of Congress Control Number: 2016943729 © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG Switzerland
Somewhere, something incredible is waiting to be known. Carl Sagan
Preface
Autophagy, a highly conserved process from yeast to mammals, is a cellular catabolitic process in which cellular components, including organelles and macromolecules, are delivered to the lysosomes for degradation. It can be classified in three principal types: microautophagy, chaperone-mediated autophagy (CMA), and macroautophagy. Microautophagy leads to degradation of sequestered portions of cytosol by direct invagination of lysosome membrane. CMA delivers cytosolic protein containing a KFERQ-like motif to the lysosomal lumen. Macroautophagy (hereafter referred to as autophagy) is the well-characterised form of autophagy that leads to the formation of a double-membraned vacuole, the autophagosome, which engulfs cytoplasmic contents (macromolecules and organelles) and fuses with lysosomes (autophagolysosomes) for cargo delivery and degradation. Materials degraded within autophagolysosomes are recruited to a
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