Targeting Autophagy in Cancer Therapy
This volume will detail the current state and perspectives of autophagy-based cancer therapy. Covering a wide range of topics, it will include an overview of autophagy as a therapeutic target in cancer, autophagy modulators as cancer therapeutic age
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Jin-Ming Yang Editor
Targeting Autophagy in Cancer Therapy
Current Cancer Research
Series Editor Wafik El-Deiry
More information about this series at http://www.springer.com/series/7892
Jin-Ming Yang Editor
Targeting Autophagy in Cancer Therapy
Editor Jin-Ming Yang Department of Pharmacology The Pennsylvania State University College of Medicine Hershey, PA, USA
ISSN 2199-2584 ISSN 2199-2592 (electronic) Current Cancer Research ISBN 978-3-319-42738-6 ISBN 978-3-319-42740-9 (eBook) DOI 10.1007/978-3-319-42740-9 Library of Congress Control Number: 2016949552 © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG Switzerland
Preface
Over the past decade or so, an ever-increasing body of scientific evidence points to the functional role and unmistakable importance of autophagy in cancer. But can autophagy be successfully exploited as a target in effective cancer therapy? It is now widely believed that modulating the activity of autophagy through targeting regulatory components in the autophagy machinery may impact the development, progression, and therapeutic outcome of cancer. Therefore, autophagy has been considered a novel and promising target for drug discovery/development and therapeutic intervention for cancer; in fact, targeting of autophagy as a therapeutic strategy in cancer has already been explored in-depth and has shown great promise. The purpose of this volume is to provide the latest updates on the current status and a unique perspective on autophagy-based cancer therapy. This volume in the Springer series, Current Cancer Research, will cover a wide range of topics, including an overview of autophagy as a therapeutic target in cancer, autophagy modulators as cancer therapeutic agents, implications of micro RNA-regulated autophagy in cancer therapy, modulation of autophag
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