Azithromycin
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Development of resistance: case report In a cohort study of 13 male patients, who tested positive for Mycoplasma genitalium at a sexually transmitted disease (STD) clinic in the USA between 8 August 2014 and 15 April 2016, a 29-year-old man was described, who developed drug resistance during treatment with azithromycin for Mycoplasma genitalium infection. The man, who had a history of having sex with multiple partners (50–99 female partners) and inconsistent condom use, was diagnosed with Mycoplasma genitalium infection related non-gonococcal urethritis. Further testing confirmed wild type infection without any resistant mutation. Hence, his treatment was with azithromycin 1g [route not stated]; however, the infection persisted. Hence, tests were performed, which showed A2058G mutation and the development of macrolide resistance-mediating mutation. Therefore, the man’s treatment was changed to moxifloxacin, that led to eradication of the Mycoplasma genitalium infection. Romano SS, et al. Long Duration of Asymptomatic Mycoplasma genitalium Infection After Syndromic Treatment for Nongonococcal Urethritis. Clinical Infectious Diseases 803500305 69: 113-120, No. 1, 1 Jul 2019. Available from: URL: http://doi.org/10.1093/cid/ciy843
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Reactions 12 Sep 2020 No. 1821
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