Bacteria and Complement
Deficiencies in any of the defense mechanisms of the host can lead to severe microbial infections; these are of clinical relevance. Broad up-to-date knowledge in this field allows identification of many unspecific as well as highly specific defense reacti
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Editors
A. Clarke, ParkvilleNictoria . R W. Compans, Birmingham/Alabama . M Cooper, Birmingham/Alabama H. Eisen, Paris . W. Goebel, Wiirzburg . H. Koprowski, Philadelphia . F. Melchers, Basel . M Oldstone, La Jolla/California . R Rott, GieBen . P.K Vogt, Los Angeles H. Wagner, U1m . I. Wilson, La Jolla/California
Bacteria and Complement Edited by Michael Loos
With 76 Figures
Springer-Verlag Berlin Heidelberg NewYork Tokyo
Prof. Dr. rer. nat. MICHAEL Loos Institut fiir Medizinische Mikrobiologie J ohannes-Gutenberg-Universitiit Obere Zahlbacher StraBe 67 D-6500 Mainz
ISBN-13: 978-3-642-45606-0
001: 10.1007/978-3-642-45604-6
e-ISBN-13: 978-3-642-45604-6
This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by photocopying machine or similar means, and storage in data banks. Under § 54 of the German Copyright Law where copies are made for other than private use, a fee is payable to "Verwertungsgesellschaft Wort", Munich © by Springer-Verlag Berlin Heidelberg 1985 Softcover reprint of the hardcover 15t edition 1985 Library of Congress Catalog Card Number 15-12910 The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product Liability: The publishers can give no guarantee for information about drug dosage and application thereof contained in this book. In every individual case the respective user must check its accuracy by consulting other pharmaceutical literature. Typesetting, printing and bookbinding: Universitiitsdruckerei H. Stiirtz AG, Wiirzburg 2123/3130-543210
Preface
Deficiencies in any of the defense mechanisms of the host can lead to severe microbial infections; these are of clinical relevance. Broad up-to-date knowledge in this field allows identification of many unspecific as well as highly specific defense reactions involved in the struggle against infectious diseases. On the other hand, protective structures on the microbial cell surfaces have been adapted and improve the counterpart's chances of survival. In particular, it has been considered that the great diversity of the bacterial envelopes not only determines the anatomical location of the tissue injury but also induces activation of distinct parts of the complex defense system. The specific defense mechanism, whose most prominent constituent is provided by the antibo
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Fig. 7. Influence of the buffer system used for measuring the bactericidal activity of 10% GPS on the S form (left) and the Re form (right) of S. minnesota. 10 3 bacteria per ml were subjected to 10% GPS for 0.5 h up to 5 h at 37° C in the presence of the following buffer system: 4 mM thioglycollate buffer, pH 7.1 (e); 0.15 M NaCl, pH 7.4
