Current Topics in Complement
Complement has long been regarded as a pivotal effector arm of the innate im-mune response, eliciting important immunoregulatory functions in the context of inflammation and also serving as a vital link between the innate and adaptive immune response. In
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ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY Editorial Board: NATHAN BACK, State University of New York at Buffalo IRUN R. COHEN, The Weizmann Institute of Science DAVID KRITCHEVSKY, Wistar Institute ABEL LAJTHA, N.S. Kline Institute for Psychiatric Research RODOLFO PAOLETTI, University of Milan
Recent Volumes in this Series Volume 576 N-ACETYLASPARTATE: A UNIQUE NEURONAL MOLECULE IN THE CENTRAL NERVOUS SYSTEM Edited by John R. Moffett, Suzannah B. Tieman, Daniel R. Weinberger, Joseph T. Coyle and Aryan M.A. Namboodiri
Volume 577 EARLY LIFE ORIGINS OF HEALTH AND DISEASE Edited by E. Marelyn Wintour and Julie A. Owens
Volume 578 OXYGEN TRANSPORT TO TISSUE XXVII Edited by Giuseppe Cicco, Duane Bruley, Marco Ferrari, and David K. Harrison
Volume 579 IMMUNE MECHANISMS IN INFLAMMATORY BOWEL DISEASE Edited by Richard S. Blumberg
Volume 580 THE ARTERIAL CHEMORECEPTORS Edited by Yoshiaki Hayashida, Constancio Gonzalez, and Hisatake Condo
Volume 581 THE NIDOVIRUSES: THE CONTROL OF SARS AND OTHER NIDOVIRUS DISEASES Edited by Stanley Perlman and Kathryn Holmes
Volume 582 HOT TOPICS IN INFECTION AND IMMUNITY IN CHILDREN III Edited by Andrew J. Pollard and Adam Finn
Volume 583 TAURINE 6: UPDATE 2005 Edited by Simo S. Oja and Pirjo Saransaari
Volume 584 LYMPHOCYTE SIGNAL TRANSDUCTION Edited by Constantine Tsoukas
Volume 585 TISSUE ENGINEERING Edited by John P. Fisher
Volume 586 CURRENT TOPICS IN COMPLEMENT Edited by John D. Lambris A Continuation Order Plan is available for this series. A continuation order will bring delivery of each new volume immediately upon publication. Volumes are billed only upon actual shipment. For further information please contact the publisher.
CURRENT TOPICS IN COMPLEMENT Edited by
John D. Lambris
Editor: John D. Lambris, Ph.D. Professor of Pathology & Laboratory Medicine University of Pennsylvania Philadelphia, PA 19107 [email protected]
Library of Congress Control Number: 2006925169 Printed on acid-free paper. ISBN 10: 0-387-32231-0 ISBN-13: 978-0387-32231-5
© 2006 Springer Science+Business Media, LLC All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed in the United States of America. 9 8 7 6 5 4 3 2 1 springer.com
Preface
Complement has long been regarded as a pivotal effector arm of the innate immune response, eliciting important immunoregulatory functions in the context of inflammation and al
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