Basic Concepts of Molecular Pathology
The Molecular Pathology Library series was created to bridge the gap between traditional basic science textbooks in molecular biology and traditional medical textbooks for organ-specific diseases. Basic Concepts of Molecular Pathology is designed as a sta
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For other titles published in this series, go to www.springer.com/series/7723
Basic Concepts of Molecular Pathology Edited by
Philip T. Cagle, MD Weill Medical College of Cornell University, New York The Methodist Hospital, Houston, Texas
and
Timothy Craig Allen, MD, JD University of Texas Health Science Center at Tyler Tyler, Texas
Editors Philip T. Cagle, MD Pathology and Laboratory Medicine Weill Medical College of Cornell University New York, NY The Methodist Hospital Houston, Texas
Timothy Craig Allen, MD, JD Department of Pathology University of Texas Health Science Center at Tyler Tyler, TX
Series editor Philip T. Cagle, MD Pathology and Laboratory Medicine Weill Medical College of Cornell University New York, NY The Methodist Hospital Houston, Texas
ISSN: 1935-987x ISBN: 978-0-387-89625-0 e-ISBN: 978-0-387-89626-7 DOI: 10.1007/978-0-387-89626-7 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2008939864 © Springer Science+Business Media, LLC 2009 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
To my wife, Kirsten Philip T. Cagle To my wife, Fran; and to Caitlin and Erin. Timothy Craig Allen
Preface
The increasing role of molecular pathology in the daily practice of medicine, including the increasingly routine use of targeted molecular therapy in personalized patient care, has created a need for textbooks that bridge the gap between medical practice and basic molecular science. Each book in the Molecular Pathology Library Series by Springer Science+Business Media provides a review of current molecular pathology for a specific organ system. The purpose of Basic Concepts of Molecular Pathology is to provide a succinct background of molecular pathology terminology and concepts to serve as a foundation and reference for understanding the medically oriented organ-specific information in the other books in the series. As such, Basic Concepts of Molecular Patho
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