Batch preparation of homogeneous size hydroxyapatite based composite ceramic microspheres
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RESEARCH
Batch preparation of homogeneous size hydroxyapatite based composite ceramic microspheres Kui Zhou 1,2,3,4 & Jiawei Zou 1 & Wenchao Chi 1 & Yanjun Lin 1 & Wenchao Li 1,4 & Chuanliang Cao 1,4 Received: 6 September 2019 / Revised: 24 June 2020 / Accepted: 20 August 2020 # Australian Ceramic Society 2020
Abstract A new and precise control printing method was developed for preparing homogeneous microspheres. Hydroxyapatite-sodium alginate (HA-SA) mixed suspension was used as printing material and CaCl2 solution was used as solidifying liquid to prepared ceramic microspheres by pneumatic extrusion printing technology. By adjusting the positive pressure, dwell time, and hydroxyapatite concentration, the influence of each parameter on the shape of printed microspheres was studied, and the suitable preparation parameters were determined. Then, the microspheres with uniform particle size distribution were successfully prepared in large quantities by selecting appropriate printing parameters. Then, the microspheres were dried and sintered at different temperatures. During the drying and sintering process, the microspheres showed obvious shrinkage, but still keep good sphericity. The phases of sintered microspheres are hydroxyapatite and calcium oxide. The microstructure shows typical hydroxyapatite grain characteristics. Keywords Pneumatic printing technology . Hydroxyapatite microspheres . Batch preparation . Sinter
Introduction Ceramic materials have the advantages of high hardness, good wear resistance, good corrosion resistance, and good insulation. They are widely used in machinery, materials, chemical, electric power, military, and other fields [1]. The ceramic microsphere generally refers to an inorganic non-metallic sintered body having a particle diameter of 50 nm to 2 mm and is spherical or nearly spherical [2]. Porous ceramic microspheres are widely used in many fields such as adsorption, catalysis, bone tissue engineering, and drug delivery [3–5].
* Chuanliang Cao [email protected] 1
School of Mechatronics Engineering, Nanchang University, Nanchang 330031, People’s Republic of China
2
Key Laboratory of Lightweight and high strength structural materials of Jiangxi Province, Nanchang University, Nanchang 330031, People’s Republic of China
3
Engineering Science and Mechanics Department, Penn State University, University Park, State College, PA 16802, USA
4
Nanchang Municipal Key Laboratory of 3D Bioprinting Technology and Equipment, Nanchang University, Nanchang 330031, People’s Republic of China
Their spherical shape provides good maneuverability, flowability, high packing density, and easy reuse after separation [6]. There are many kinds of ceramic microspheres, such as SiO2/SiCN core-shell ceramic microspheres, cermet microspheres, and calcium phosphate bioceramic microspheres [7–9]. In particular, porous hydroxyapatite ceramic microspheres have good biocompatibility and bioactivity and are similar to inorganic substances in hard tissue bone and teeth in chemical composition and structure. Th
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