Preparation and characterization of a novel polylactic acid/hydroxyapatite composite scaffold with biomimetic micro-nano
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B I O M A T E R I A L S S Y N T H E S I S A N D CH A R A C T E R I Z A T I O N Original Research
Preparation and characterization of a novel polylactic acid/hydroxyapatite composite scaffold with biomimetic micro-nanofibrous porous structure Shuqiong Liu1,2 Yuying Zheng ●
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Ruilai Liu2 Chao Tian2 ●
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Received: 11 November 2019 / Accepted: 20 July 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Combining synthetic polymer scaffolds with inorganic bioactive factors is widely used to promote the bioactivity and bone conductivity of bone tissue. However, except for the chemical composition of scaffold, the biomimetic structure also plays an important role in its application. In this study, we report the fabrication of polylactic acid/hydroxyapatite (PLA/HA) composite nanofibrous scaffolds via phase separation method to mimic the native extracellular matrix (ECM). The SEM analysis showed that the addition of HA dramatically impacted the morphology of the PLA matrix, which changed from 3D nanofibrous network structure to a disorderly micro-nanofibrous porous structure. At the same time, HA particles could be evenly dispersed at the end of the fiber. The FTIR and XRD demonstrated that there was not any chemical interaction between PLA and HA. Thermal analyses showed that HA could decrease the crystallization of PLA, but improve the thermal decomposition temperature of the composite scaffold. Moreover, water contact angle analysis of the PLA/HA composite scaffold demonstrated that the hydrophilicity increased with the addition of HA. Furthermore, apatite-formation ability tests confirmed that HA could not only more and faster induced the deposition of weak hydroxyapatite but also induced specific morphology of HA. Graphical Abstract
1 Introduction Supplementary information The online version of this article (https:// doi.org/10.1007/s10856-020-06415-4) contains supplementary material, which is available to authorized users.
Repairing bone defects and curing bone diseases are the primary aim of bone tissue engineering. Treatment
* Yuying Zheng [email protected]
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College of Materials Science and Engineering, Fuzhou University, Fuzhou 350108, PR China
College of Ecology and Resource Engineering, Wuyi University, Wuyishan 354300, PR China
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Journal of Materials Science: Materials in Medicine (2020)31:74
strategies include using a porous scaffold implanted in the defect site to induce natural bone growth or transplanting a three-dimensional (3D) scaffold with osteoblasts from a living organism. Either way, the scaffold plays a role of temporary physical support and primitive cell adsorption, and provide the space for the regeneration of new bone [1, 2]. Appropriate 3D nanofibrous scaffolds play an important role in maintaining cell viability and phenotype expression and are also an important direction for scaffold research [3, 4]. Therefore, the selection of scaffold material and structure must meet the physical properties and biolog
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