Bicomponent nanofibrous scaffolds with dual release of anticancer drugs and biomacromolecules
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Research Letter
Bicomponent nanofibrous scaffolds with dual release of anticancer drugs and biomacromolecules Yu Zhou, Department of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong Qilong Zhao , Department of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong; Institute of Biomedical & Health Engineering, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), Shenzhen, 518055, China Natasha L.Y. Tsai, and Min Wang, Department of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong Address all correspondence to Dr. Q. Zhao, Prof. M. Wang at [email protected], [email protected] (Received 21 November 2018; accepted 12 February 2019)
Abstract Multifunctional scaffolds with dual release of small molecular drugs and biomacromolecules have potential in many applications such as cancer postoperative care, which require appropriate administration of anticancer drugs and biomacromolecules in a spatiotemporal manner. Herein, a systematic investigation into the dual release of anticancer drugs and biomacromolecules from the bicomponent nanofibrous scaffolds is performed. Their release behavior is affected by different fabrication techniques and different polymers used. We show that the bicomponent scaffold fabricated by dual-source dual-power emulsion electrospinning enables dual release of anticancer drugs and biomacromolecules in a controlled manner, holding promise for combinational cancer postoperative care.
Introduction Tissue engineering has emerged in recent decades for treating injuries or disorders of human body tissues that are difficult to be cured by conventional methods.[1] In tissue engineering, scaffold-based strategies are popular as tissue-engineered scaffolds with well-designed properties can provide an appropriate structural and mechanical platform for supporting cell growth and tissue regeneration.[2] Nanofibrous scaffolds are of high interest owing to their resembling structure to the natural extracellular matrix (ECM), hence offering biomimetic structural cues for directing cell attachment and cell function.[3] Electrospinning, a simple yet effective technique for fabricating nanofibers, has been widely employed and investigated for the fabrication of nanofibrous tissue-engineered scaffolds.[4–6] However, conventional electrospun scaffolds lack desirable functionalities for desirable therapeutic effects. Through specifically adapted electrospinning, nanofibrous scaffolds can be tailored for the delivery of various cargo substances, ranging from small molecular drugs or biomacromolecules to even living mammalian cells,[7] which bring the possibility to endow scaffolds with different functions. For example, electrospun scaffolds have been investigated for the delivery of small molecular anticancer drugs such as doxorubicin hydrochloride (DOX), showing potential in cancer treatment.[8] Electrospun scaffolds with controlled release of biomacromolecules such as growth factors have been also shown to enhance b
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