Bio-inspired Self-Assembly of Micro and Nano-Structures for Sensing and Electronic Applications
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Bio-inspired Self-Assembly of Micro and Nano-Structures for Sensing and Electronic Applications H. McNally1, S.W.Lee1, D.Guo1, M.Pingle2, D.Bergstrom2, R.Bashir1,3 School of Electrical and Computer Engineering1, Department of Medicinal Chemistry2, Department of Biomedical Engineering3, Purdue University, W. Lafayette, IN 47907
ABSTRACT Bio-inspired assembly, through the use of bio-molecules such as DNA and proteins, will play a critical role in the advancement of novel sensing techniques and for the realization of heterogeneous integration of materials. For many of these applications, such as antibody-based biosensor and the study of controlled cell growth, DNA and protein patterning techniques are crucial. We will present an update of our work on protein patterning techniques using microelectronic fabrication, DNA hybridization and biotin-streptavidin pairing. To show its application in biological inspired self-assembly, this technique was used successfully in the selfassembly of 20 nm streptavidin conjugated gold particles. In addition, the integration of nanoand micro-scale heterogeneous materials is very important for novel material synthesis and electro-optic applications. We will present an update on our work to assemble silicon electronic devices using DNA/charged molecules and electric fields. Devices are fabricated, released, charged with molecules, and subsequently manipulated in electric fields. The techniques described can be used to integrate the hybrid devices such as nano- or micro-scale resistors, PN diodes, and MOSFETs on silicon or other substrates such as glass, plastic, etc.
INTRODUCTION Self-Assembly techniques have experienced a tremendous increase in research activity over the recent years. Applications such as the integration of heterogeneous materials for electronic application, development of nano-scale electronic devices, biological and chemical sensing, and medical diagnostics may all benefit from the understanding of self-assembly processes. Self-assembly of useful devices may come in the form of biological [1,2], chemical [3], electrostatics [4], or fluidics [5] as well as any combination of these techniques. To controllably manipulate structures at the micro and nano-meter scale is a challenge, once accomplished, will lead to a new generation of materials and detection schemes. Nature assembles nano-scale components using molecular recognition. In the case of DNA, hydrogen bonding is the driving force behind the matching of complementary pairs of single-stranded (ss) DNA to hybridize into a double strand (ds) of helical DNA. It has been estimated that each base pair binds with 0.5kCal/mol of energy [6]. For the use of a 18mer oligonucleotide, the binding energy can be estimated at around 9kCal/mol. However, the actual binding energy of a dsDNA is dependent on the base-pair sequence, salt concentration of surrounding media, temperature, among others. In the case of antibodies/antigens and ligands/receptors, binding takes places by a combination of electrostatic forces, chemica
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