Biochemical and Pharmacological Differentiation of Neuroleptic Effect on Dopamine D-1 and D-2 Receptors
In dopamine (DA) receptor binding tests two different receptor populations can be measured. By using 3H-haloperidol or 3H-spiroperidol as ligands D-2 receptors are detected. When the thioxanthene neuroleptics 3H-cis (Z)-flupenthixol or 3H-piflutixol are u
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Basic Aspects of Receptor Biocheltlistry
Springer- Verlag Wien GlDhH
Journal of Neural Transmission Supplementum 18
Basic Aspects of Receptor Biochentistry Proceedings of the International Symposium,Vienna, September 10-12, 1982 Edited by M.Goldstein, K. Jellinger, and P. Riederer
Springer-Verlag Wi en GmbH
Prof Dr. Menek Goldstein
Department' of Psychiatry, New York University Medical Center, New York, N.Y., U.S.A.
Prof Dr. Kurt Jellinger
Ludwig Boltzmann-Institut flir Klinische Neurobiologie und Neurologische Abteilung, Krankenhaus der Stadt Wien-Lainz, Wien, Austria
Prof. Dr. Peter Riederer
Ludwig Boltzmann-Institut fiir Klinische Neurobiologie Krankenhaus der Stadt Wien-Lainz, Wien, Austria
This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by photocopying machine or similar means, and storage in data banks. © 1983 by Springer-Verlag Wien Originally published by Springer-Verlag Wien-New York in 1983 Softcover reprint of the hardcover I st edition 1983
With 100 Figures
Library of Congress Cataloging in Publication Data. Main entry under title: Basic aspects of receptor biochemistry. Oournal of neural transmission. Supplementum, ISSN 0303-6995-; 18) "Symposium on 'Basic Aspects in Brain Receptor Biochemistry', organized by the Ludwig Boltzmann-Institute of Clinical Neurobiology, Vienna"-P. 1. Neurotransmitter receptorsCongresses. I. Goldstein, Menek. II. ]ellinger, K (Kurt), 1931- . III. Riederer, P., 1942- . IV. Ludwig Boltzmann-Institut ftir Klinische Neurobiologie. V. Symposium on "Basic Aspects in Brain Receptor Biochemistry" (1982 : Vienna, Austria). VI. Series. [DNLM: 1. Receptors, Sensory-Congresses. WI ]0781A no. 18 ! WL 102.9 B3111982]. QP364.7.B37. 1983. 599.01'88. 83-4762
ISBN 978-3-7091-4410-7
ISSN 0303-6995
ISBN 978-3-7091-4408-4 (eBook)
DOl 10.1007/978-3-7091-4408-4
Preface In recent years a number of research fields in biology have focussed on the concept of receptors. The selective binding of small molecules to specific sites of the cell membrane is being increasingly recognized as the basic mechanism by which cells communicate with each other. It has been shown that neurotransmitters, hormones and drugs must first interact with specific receptors in order to elicit their biochemical, physiological, and pharmacological effects. The basic field of "cellular receptors" and the fundamental concepts of receptor activity embrace a broad spectrum of biomolecular interactions which have been the subject of intense investigations. Although considerable progress has been made in the understanding of the receptor-related phenomena, e.g. the location, sensitivity, and kinetics of neurotransmitter receptors, little progress has been made in elucidating the structures of receptors and the biochemical and biophysical components coupled to them. Many basic problems in the function and dysfunction of receptors and their importance
