Biocorrosion resistance and biocompatibility of Mg-Al layered double hydroxide/poly(L-lactic acid) hybrid coating on mag
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RESEARCH ARTICLE
Biocorrosion resistance and biocompatibility of Mg–Al layered double hydroxide/poly(L-lactic acid) hybrid coating on magnesium alloy AZ31 Xiang SUN1, Qing-Song YAO1, Yu-Chao LI2, Fen ZHANG (✉)1, Rong-Chang ZENG (✉)1,3, Yu-Hong ZOU4, and Shuo-Qi LI1 1 Corrosion Laboratory for Light Metals, College of Materials Science and Engineering, Shandong University of Science and Technology, Qingdao 266590, China 2 School of Materials Science and Engineering, Liaocheng University, Liaocheng 252059, China 3 School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450002, China 4 College of Chemical and Environmental Engineering, Shandong University of Science and Technology, Qingdao 266590, China
© Higher Education Press 2020
ABSTRACT: A Mg-Al layered double hydroxide (Mg-Al-LDH) coating was firstly synthesized via an in-situ steam coating growth method on the AZ31 Mg alloy, and then was modified with poly(L-lactic acid) (PLLA) via dipping and vacuum freeze-drying. The microstructure and composition of LDH/PLLA hybrid coating were analyzed by XRD, SEM, EDS and FT-IR. The biocorrosion behavior of hybrid coating was evaluated by potentiodynamic polarization, electrochemical impedance spectroscopy (EIS) and hydrogen evolution test in the Hank’s solution. The results showed that LDH/PLLA coatings exhibited a much dense layer compared to the unmodified Mg-Al-LDH coating with unobvious boundary between PLLA and LDH coatings. The corrosion current density of the LDH/PLLA-10 hybrid coating decreased three orders of magnitude in comparison to its substrate. It was proven that the existence of the PLLA coating further prolonged the service life of the Mg-Al-LDH coating. What’s more, the MTT assay and live/ dead staining showed that the LDH/PLLA-10 coating had good biocompatibility for Mouse NIH3T3 fibroblasts. The formation mechanism and the anti-corrosion mechanism of hybrid coatings were proposed. KEYWORDS: magnesium alloy; layered double hydroxide; poly(L-lactic acid); corrosion resistance; biocompatibility
Contents 1 Introduction 2 Experimental 2.1 Materials and chemicals 2.2 Preparation of the Mg–Al-LDH coating Received June 5, 2020; accepted August 1, 2020 E-mails: [email protected] (F.Z.), [email protected] (R.C.Z.)
2.3 2.4 2.5 2.6
Preparation of LDH/PLLA hybrid coatings Surface analysis Corrosion studies Cytocompatibility evaluation 2.6.1 Cell proliferation assays 2.6.2 Live/dead cell staining 3 Results 3.1 Microstructure and chemical compositions of coatings
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3.2 Corrosion behavior 3.3 Cytocompatibility evaluation 4 Discussion 4.1 Comparison in anti-corrosion of polymer coatings on Mg alloys 4.2 Coating formation mechanism 4.3 Corrosion mechanism 5 Conclusions Acknowledgements References
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Introduction
Magnesium (Mg) alloys have been widely considered as the next generation of biomedical materials because of their good biocompatibility, complete in vivo degradation, good mechanical strength, and suitable elastic modulus for human [1–5]. However, rapid corr
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