Biological Evaluation of Synthesized Schiff Base-Metal Complexes Derived from Sulfisomidine
- PDF / 965,875 Bytes
- 9 Pages / 595.276 x 790.866 pts Page_size
- 49 Downloads / 220 Views
ORIGINAL ARTICLE
Biological Evaluation of Synthesized Schiff Base-Metal Complexes Derived from Sulfisomidine Amina Mumtaz 1 & Tariq Mahmud 2 & Maryam Khalid 2 & Huma Khan 2 & Aatika Sadia 2 & Malka M. Samra 2 & Muhammad Asim Raza Basra 2
# Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Purpose Inflammation characterized by edema, redness, and pain predominantly symptomatizes in diseases like allergies, asthma, and arthritis. Anti-inflammatory drugs like NSAIDs have been used to treat inflammation but reportedly cause severe gastrointestinal problems; therefore, new and safer drugs are sought-after for better resolution of diseases. The metal-based drugs have been proved as promising alternatives for some of the currently used drugs. The aim of this study was to evaluate antioxidant, antibacterial, and in vivo and in vitro anti-inflammatory activities of new Schiff base derived metal complexes. Methods The antioxidant, antibacterial, and in vivo and in vitro anti-inflammatory activities were performed by 2,2-diphenyl-1picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), agar well diffusion, paw edema, and egg albumin denaturation methods respectively. Results Mn (II) and Co (II) complexes showed 0.65 and 1.91 IC50 values and other complexes showed compelling ABTS antioxidant activity. Cu (II) and Zn (II) complexes exhibited significant antimicrobial activity against all six bacterial strains as compared with the parent Schiff base ligand. Conclusion The in vitro anti-inflammatory activity revealed that all the complexes inhibited inflammation in dose-dependent manner, while in vivo results indicated Ni (II) complex as potential anti-inflammatory agent. Hence our drugs were found to be potent antioxidant, antibacterial, as well as anti-inflammatory agents and might be used to suppress disease severity by inhibiting the inflammation. Keywords Schiff base . Transition metal complexes . Sulfisomidine . Anti-inflammatory . Antioxidant . Antibacterial
Introduction Inflammation is one of the key symptoms of diseases like rheumatoid arthritis, allergic asthma, and bacterial infections. It is characterized by percolation of lymphatic fluid causing edema, redness, and pain [1]. Infections caused by pathogenic bacteria trigger complicated inflammation in the body that is a common problem worldwide and requires potent antibacterial agents to aid antimicrobial defense [2]. The production of
* Muhammad Asim Raza Basra [email protected] 1
Applied Chemistry Research Centre, Pakistan Council of Scientific and Industrial Research Laboratories Complex, Lahore 54600, Pakistan
2
Institute of Chemistry, University of the Punjab, New Campus, Lahore 54590, Pakistan
reactive oxygen species (ROS) generates oxidative stress that deteriorates the organ systems of the body. This degeneration causes more recurrent inflammation [3]. Worldwide prevalence of rheumatoid arthritis is approximately 1.5% [4] and that of asthma is 11.4% [5] which indicates much requirement for
Data Loading...
