Biology in Stem Cell Niche
This comprehensive volume explores functions, pathologies, and applications of stem cells in relation to the niches in which they develop. Ten chapters cover the subject in depth, from a historical perspective through signaling, hormonal control, quiescen
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Kursad Turksen Editor
Biology in Stem Cell Niche
Stem Cell Biology and Regenerative Medicine Series editor Kursad Turksen, Ph.D. e-mail: [email protected]
More information about this series at http://www.springer.com/series/7896
Kursad Turksen Editor
Biology in Stem Cell Niche
Editor Kursad Turksen Ottawa, ON Canada
ISSN 2196-8985 ISSN 2196-8993 (electronic) Stem Cell Biology and Regenerative Medicine ISBN 978-3-319-21701-7 ISBN 978-3-319-21702-4 (eBook) DOI 10.1007/978-3-319-21702-4 Library of Congress Control Number: 2015944741 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Humana Press is a brand of Springer Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www.springer.com)
Preface
While our notion of the existence of stem cells has been extant for more than 50 years, deciphering details of regulation of their self-renewal and maintenance potential has been an ongoing effort. The concept that a protected and nurturing location or environment was key to this regulation was first proposed by R. Scholfied in 1978. Since then, numerous—both physical and biological— potential components have been investigated, and a large number of so-called stem cell niche components have now been identified. As importantly, how systemic or epigenetic factors, or injury or disease states, or even normal aging can modulate functional aspects of the stem cell niche have become key questions over the last decade. Deconstruction of the stem cell niche and its reconstruction as biomimetic or engineered constructs in potential regenerative medicine applications are now also hot topics. Authors of chapters in this volume have tackled a range of these topics, summarizing advances made and challenges and opportunities lying ahead. I thank all the contributors for sharing their expertise and time in putting together
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