Role of growth factors in hematopoietic stem cell niche
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REVIEW
Role of growth factors in hematopoietic stem cell niche Dabin Lee & Dong Wook Kim & Je-Yoel Cho
Received: 30 March 2019 / Accepted: 16 December 2019 # Springer Nature B.V. 2020
Abstract Hematopoietic stem cells (HSCs) produce new blood cells everyday throughout life, which is maintained by the self-renewal and differentiation ability of HSCs. This is not controlled by the HSCs alone, but rather by the complex and exquisite microenvironment surrounding the HSCs, which is called the bone marrow niche and consists of various bone marrow cells, growth factors, and cytokines. It is essential to understand the characteristic role of the stem cell niche and the growth factors in the niche formation. In this review, we describe the role of the bone marrow niche and factors for niche homeostasis, and also summarize the latest research related to stem cell niche. Keywords Hematopoietic stem cell . Hematopoiesis . Osteoblastic niche . Perivascular niche . Sinusoidal niche
Introduction Hematopoietic stem cells (HSCs) have differentiation potential as a major component of blood cells. Since the lifespan of blood cells is relatively short and they are D. Lee : D. W. Kim : J.
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