Biology of the Arterial Wall
Biology of the Arterial Wall is intended as a general reference text concerned with the biology of the vascular cells and the blood vessel wall under physiological and pathological conditions. One of the major functions of the arteries is to maintain a co
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BASIC SCIENCE FOR THE CARDIOLOGIST
1.
B. Levy, A. Tedgui (eds.): Biology ofthe Arterial Wall 1999 ISBN 0-7923-8458-X
KLC~WERACADEMIC PUBLISHERS - DORDRECHT/BOSTON/LONDON
Biology of the Arterial Wall
edited by Bernard I. Levy
and Alain Tedgui INSERM U747 Lariboisiere hospital Paris, France
Distributors for North, Central and South America: Kluwer Academic Publishers 101 Philip Drive Assinippi Park Norwell, Massachusetts 0206 1 USA Distributors for all other countries: Kluwer Academic Publishers Group Distribution Centre Post Office Box 322 3300 AH Dordrecht, THE NETHERLANDS Library of Congress Cataloging-in-PublicationData
Biology of the arterial wall 1 edited by Bernard I. Levy and Alain Tedgui. p. cm. (Basic science for the cardiologist ; 1) Includes index. ISBN 0-7923-8458'-X 1. Arteries--Physiology. 2. Arteries--Pathophysiology. I. LCvy, Bernard I. 11. Tedgui, Alain. 111. Series. [DNLM: 1. Arteries--physiology. 2. Arteries--pathology. WG 5 10 B615 19991 QP106.2.BS6 1999 612. 1'33--dc21 DNLM/DLC 98-55059 for Library of Congress CIP
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Copyright 0 1999 by Kluwer Academic Publishers
All rights reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, mechanical, photocopying, recording, or otherwise, without the prior written permission of the publisher, Kluwer Academic Publishers, 101 Philip Drive, Assinippi Park, Norwell, Massachusetts 02061 Printed on acid-free paper
Printed in the United States of America
Dedicated to Jacques Maclouf
Contents List of Contributors Preface Bernard I. Levy and Alain Tedgui .............................................
IX Xlll
I. The Vascular Wall under Physiological Conditions I. Morphologic aspects of the large artery vascular wall Bernard I. Levy and Alain Tedgui ................................................ 3
2. Mechanics of the large artery vascular wall Bernard I. Levy ..........................................................................
13
3. Neurohumoral control of the vascular system Stephane Laurent ...................................................................... 25
4. Endothelialfunction and dysfunction Paul Vanhoutte and Chantal Boulanger ..................................... 49 5. Mechanical factors and vascular biology Alain Tedgui, Stephanie Lehoux and Bernard I. Levy ................. 71 6. Angiogenic growth factors Cedric J. Gaultier and Jean-Baptiste Mchel ............................ 101
7. Angiogenesis Hany A.J. Struijker Boudier, Fmnk R.M. Stassen and Ferdinand A. C. le Noble............................................................ 115 8. Vascular aging Jolil Belmin .............................................................................
129
II. The Vascular Wall under Pathological Conditions .......... 149 9. Vessel and inflammation Catherine Bernard ..................................................................... 151
10. Apoptosis in normal and pathological vessels Ziad Mallat and Alain Tedgui.........................................
