Biomechanical role of osteoporosis affects the incidence of adjacent segment disease after percutaneous transforaminal e
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(2019) 14:131
RESEARCH ARTICLE
Open Access
Biomechanical role of osteoporosis affects the incidence of adjacent segment disease after percutaneous transforaminal endoscopic discectomy Jingchi Li1,2, Wenqiang Xu1, Xiaoyu Zhang2, Zhipeng Xi1 and Lin Xie1,2*
Abstract Study design: Variation in the biomechanical characteristics of intervertebral discs adjacent to the segment disc after undergoing percutaneous transforaminal endoscopic discectomy (PTED) in models with normal and abnormal bone mineral density (BMD) was estimated using the finite element method. Objective: The study investigated the change in the incidence of adjacent segment disease (ASD) after PTED in patients without and with osteoporosis. Backgrounds: PTED has been widely used for treating lumbar disc herniation (LDH); changes in BMD will affect biomechanical characteristics, possibly leading to changes in the incidence of ASD after PTED. However, this issue remains largely unclear. Methods: A non-linear, lumbosacral finite element model was reconstructed based on imaging data and validated using compared values computed by the current model from published and well-validated, in vitro biomechanical experiment studies. Corresponding PTED models with normal and abnormal BMDs were also reconstructed. Shear and von Mises stresses on the annulus fibrosis, the von Mises stress on the endplates in L5–S1 segment discs, and the total deformation of current lumbosacral models were computed in different body positions by changing loading conditions, including flexion, extension, left and right lateral bending, and axial rotation. Results: In most loading conditions, biomechanical characteristics of the lumbosacral segment discs with normal BMDs after PTED slightly increased. However, in the PTED model with osteoporosis, most of the biomechanical characteristics dramatically increased. Conclusion: Osteoporosis leads to the deterioration of biomechanical characteristics in the adjacent segment disc after PTED; this variation may also result in an increase in the incidence of ASD. However, further studies on the interactions between pathological changes are warranted. Keywords: Adjacent segment diseases, Percutaneous transforaminal endoscopic discectomy, Osteoporosis, Bone mineral density, Finite element method
* Correspondence: [email protected] 1 Department of Orthopedic Surgery, Jiangsu Province Hospital on Integration of Chinese and Western Medicine, 100th Shizi Street, Nanjing 210028, Jiangsu, People’s Republic of China 2 Department of Spine Surgery, Third Clinical Medical College of Nanjing University of Chinese Medicine, Nanjing 210028, Jiangsu, People’s Republic of China © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons lice
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