Biomedical Applications of Acridines Derivatives, Syntheses, Proper
This book describes applications of acridines for the treatment of various neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and various prion diseases, and discusses the potential of acridines in neuro-regenerative medicine. U
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Jan Ježek Jan Hlaváček Jaroslav Šebestík
Biomedical Applications of Acridines Derivatives, Syntheses, Properties and Biological Activities with a Focus on Neurodegenerative Diseases
Progress in Drug Research Volume 72
Series editor K.D. Rainsford, Sheffield Hallam University, Biomedical Research Centre, Sheffield, UK
More information about this series at http://www.springer.com/series/4857
Jan Ježek Jan Hlaváček Jaroslav Šebestík •
Biomedical Applications of Acridines Derivatives, Syntheses, Properties and Biological Activities with a Focus on Neurodegenerative Diseases
123
Jaroslav Šebestík Academy of Sciences Institute of Organic Chemistry and Biochemistry Prague Czech Republic
Jan Ježek Academy of Sciences Institute of Organic Chemistry and Biochemistry Prague Czech Republic Jan Hlaváček Academy of Sciences Institute of Organic Chemistry and Biochemistry Prague Czech Republic
ISSN 0071-786X Progress in Drug Research ISBN 978-3-319-63952-9 DOI 10.1007/978-3-319-63953-6
ISSN 2297-4555
(electronic)
ISBN 978-3-319-63953-6
(eBook)
Library of Congress Control Number: 2017947442 © Springer International Publishing AG 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
To memory of the late Dr. Dušan Drahoňovský, who contributed to the concept of human friendly science. He served as a very kind and good teacher of organic chemistry at Charles University, Prague. When we had started to study organic synthesis at University of Pardubice, Dušan’s nickname was Acridine, because he had been devoted to carry out acridine synthesis since high school age.
Acknowledgements
This work was supported by the Czech Science Foundation (14-00431S
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