Biophysical Aspects of Transmembrane Signaling

Transmembrane signaling is one of the most significant cell biological events in the life and death of cells in general and lymphocytes in particular. Until recently biochemists and biophysicists were not accustomed to thinking of these processes from the

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S. Damjanovich (Ed.)

Biophysical Aspects of Transmembrane Signaling With 41 Figures, 17 in Color and 5 Tables

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Professor Sandor Damjanovich MD. DSc. Department of Biophysics and Cell Biology University of Debrecen Medical and Health Science Center H-4012 Debrecen Nagyerdei krt.98. Hungary

ISSN 0932-2353 ISBN-10 3-540-25064-6 Springer-Verlag Berlin Heidelberg New York ISBN-13 978-3-540-25064-7 Springer-Verlag Berlin Heidelberg New York Library of Congress Control Number: 2005921138 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. Springer-Verlag is a part of Springer Science+Business Media springeronline.com © Springer-Verlag Berlin Heidelberg 2005 Printed in Germany The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Editor: Dr. Sabine Schreck, Heidelberg Desk Editor: Anette Lindqvist, Heidelberg Production: ProEdit GmbH, Heidelberg Typesetting: Satz-Druck-Service, Leimen Cover Design: Design & Production, Heidelberg Printed on acid-free paper

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Preface

Writing or editing a book on a very topical field of science is always a great challenge, since by the time the book is published some of the newest and latest findings might be obsolete compared with results reported in the most current issues of various high-level journals. Nevertheless, stimulating good books describe complicated systems and interrelationships and provide a broad spectrum of material for talented researchers who may find new inspiration from a joint presentation of correlated data. Of course, an editor cannot rank his own book. However, in this case, the contributing authors have high scientific standards and well-known achievements which speak for themselves. Transmembrane signaling has many different forms and biochemical and biophysical details. However, the final outcome of transmembrane signaling at the cellular level elucidates some cellular functions, which are at the center of selfdefense, alimentation, escape reactions, etc. Transmembrane signaling can be studied best in the immune system, in particular in lymphocytes, the main cellular carriers of immune defense. The different chapters are independent studies, written by well-known experts in their particular fields. Some chapters include the authors’ very recent data, generalized, on the one hand, to provide understan