Biophysics and Synchrotron Radiation
This book the second volume in the "Springer Series in Biophysics" col lects together contributions to the conference on "Biophysics and Syn chrotron Radiation" held in July 86 at Frascati. This meeting addressed the advances on the structure of biologi
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Springer Series in Biophysics Volume 1 Structure, Dynamics and Funktion of Biomolecules Edited by A. Ehrenberg, R. Rigler, A. Graslund and L. Nilsson Volume 2 Biophysics and Synchrotron Radiation Edited by A. Bianconi and A. Congiu Castellano
Biophysics and Synchrotron Radiation Edited by A. Bianconi and A. Congiu Castellano
With 192 Figures
Springer-Verlag Berlin Heidelberg New York London Paris Tokyo
Preface
This book the second volume in the "Springer Series in Biophysics" collects together contributions to the conference on "Biophysics and Synchrotron Radiation" held in July 86 at Frascati. This meeting addressed the advances on the structure of biological molecules obtained by using synchrotron radiation. In fact it was most timely to review the results of the research in biophysics which is rapidly developing at synchrotron radiation facilities. Moreover, there was interest to discuss the new perspectives opened up by the future high brilliance synchrotron radiation sources. With the use of synchrotron radiation, x-ray spectroscopy of biological molecules is firmly established in the techniques of EXAFS and XANES. Contributions to the detailed knowledge of local structure of active sites of metalloproteins by this approach are presented in this volume, together with a number of studies of -the interaction of metal ions with other important biological macromolecular systems. Structural determination of very large biological systems at high resolution, including a protein and its substrate, are reported. The experimental advances in protein crystallography presented here reduce the time for solving protein structures, thus satisfying a major requirement of the rapidly-expanding field of protein engineering. Great scientific interest is now concentrated on detecting the dynamics of the structure of biological molecules, related to their biological function. In this volume new experimental approaches to this problem are presented, showing the enormous potential offered by synchrotron radiation in introducing the dimension of time into x-ray diffraction, x-ray scattering and x-ray spectroscopy. The success of this meeting was already ensured by the large and enthusiastic participation of the leading scientists in the field, and prolonged discussions in a friendly atmosphere. We hope that these contributions to this exciting area of biophysical research will now be enjoyed by a wider audience. A. BIANCONI
A. CONGIU CASTELLANO
Contents
X-Ray Diffraction The Impact ofSyrichrotron Radiation on Protein Crystallography G. Dodson •••.•..•••••••.•.•••..••.•••••••.•.•.•••.•.•.•••.•••••.•
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Crystallography of the Complex tRNA ASP-Aspartyl-tRNA Synthetase from Yeast J. Cavarelli, R. Giege, A. Podjarny, B. Rees, M. Roth, J.C. Thierry and D. Moras (With 2 Figures) ••..•••....•..•••.•••..•••••.••.•••• 10 Time-Resolved X-Ray Fibre Diffraction Studies of Structural Transitions in the DNA Double-Helix Using the Daresbury SRS W. Fuller, V.T. Forsyth, A. Mahendrasingam, R.J. Greenall, W.J. Pigram and K. Bellamy (Wit
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