Bioreaction Engineering Principles
The present text is a complete revision of the 2nd edition from 2003 of the book with the same title. In recognition of the fast pace at which biotechnology is moving we have rewritten several chapters to include new scientific progress in the field from
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John Villadsen
l
Jens Nielsen
l
Gunnar Lide´n
Bioreaction Engineering Principles Third Edition
John Villadsen Department of Chemical and Biochemical Engineering Technical University of Denmark (DTU) Lyngby, Denmark [email protected]
Gunnar Lide´n Department of Chemical Engineering Lund University Lund, Sweden
Jens Nielsen Systems Biology Chalmers University of Technology Gothenburg, Sweden [email protected]
ISBN 978-1-4419-9687-9 e-ISBN 978-1-4419-9688-6 DOI 10.1007/978-1-4419-9688-6 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011931856 # Springer Science+Business Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
In early 2009, we were approached by Springer Verlag, the company that had absorbed Kluwer Academic/Plenum Publishers. The second edition of our textbook “Bioreaction Engineering Principles” was now sold out, and we were asked to prepare a third edition. With very little hesitation we accepted the offer. Since 2003 the book has been used as course-book, in European universities and also in North and South America, in the Far East, and in Australia. We wished not only to revise the text, but also to write a book that would appeal to students at the best universities, at least until 2020. In short courses given at major Biotech companies we have also found that some of the material in the previous editions could be used right away to give the companies a better understanding of their processes and to propose better design of their reactors. This acceptance of the book by the industrial community prompted us to include even more examples relevant for design of processes and equipment in the industry. The changes that have been made since the second edition are outlined in the first, introductory chapter of the present edition. Our initial enthusiasm to embark on a complete revision of the text was mollified by the duties imposed on two of us (J.N. and G.L.) in handling large research groups and with the concomitant administration. One of us (J.V.) had much more time available in his function as senior professor, and he became the main responsible person for the work during the almost 2 years since the start of the project. But we are all happy with the result of our common
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