Biotin
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Biotin Detection of false-positive thyroid-specific autoantibodies : case report A 47-year-old man exhibited false-positive thyroid-specific autoantibodies in the setting of biotin administration for multiple sclerosis (MS). The man, who had MS, presented for a routine follow-up, and underwent a series of laboratory tests in order to alter his ongoing drug therapy for MS [not all specific drugs stated]. Investigation for thyroid-specific autoantibodies, performed by an immunoassay returned positive (indicative of hyperthyroidism). However, the finding could not be correlated with any clinical derangements. Therefore, no hyperthyroidism therapy was given. On further anamnesis it was revealed that he had been receiving biotin 300mg daily [route not stated] for underlying MS. A repeat thyroid investigation with a non-biotinylated assay gave normal results. Author comment: "It should be borne in mind that discrepancies between the clinical presentation and the laboratory findings of patients taking biotin may be due to biotin interference with the test. The test values that may be affected. . . Biotin intake should be paused two to five days before streptavidin-biotin-based assays are used." Kohler VF, et al. Biotin Interference in the Measurement of Thyroid Hormone. Deutsches Arzteblatt International 115: 500, No. 29, Jul 2018. Available from: 803433146 URL: http://doi.org/10.3238/arztebl.2018.0500 - Germany
0114-9954/19/1778-0001/$14.95 Adis © 2019 Springer Nature Switzerland AG. All rights reserved
Reactions 9 Nov 2019 No. 1778
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