Bipolar Depression: Molecular Neurobiology, Clinical Diagnosis, and Pharmacotherapy
This book brings together mental health professionals and researchers to offer the most up-to-date information on the diagnosis, treatment, and research surrounding bipolar depression. Its individual chapters provide valuable diagnostic information, allow
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Carlos A. Zarate Jr. Husseini K. Manji Editors
Bipolar Depression: Molecular Neurobiology, Clinical Diagnosis, and Pharmacotherapy Second Edition
Milestones in Drug Therapy
Series Editors Michael J. Parnham, Fraunhofer IME & Goethe University, Frankfurt, Germany Jacques Bruinvels, Bilthoven, The Netherlands Advisory Board J.C. Buckingham, Imperial College School of Medicine, London, UK R.J. Flower, The William Harvey Research Institute, London, UK A.G. Herman, Universiteit Antwerpen, Antwerp, Belgium P. Skolnick, National Institute on Drug Abuse, Bethesda, MD, USA
More information about this series at http://www.springer.com/series/4991
Carlos A. Zarate Jr. • Husseini K. Manji Editors
Bipolar Depression: Molecular Neurobiology, Clinical Diagnosis, and Pharmacotherapy
Second Edition
Editors Carlos A. Zarate Jr. Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health Bethesda, MD, USA
Husseini K. Manji Janssen Pharmaceuticals of Johnson and Johnson, Janssen Research and Development Titusville, NJ, USA
ISSN 2296-6056 ISSN 2296-6064 (electronic) Milestones in Drug Therapy ISBN 978-3-319-31687-1 ISBN 978-3-319-31689-5 (eBook) DOI 10.1007/978-3-319-31689-5 Library of Congress Control Number: 2016958584 © Springer International Publishing Switzerland (outside the USA) 2009, 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG Switzerland
Preface
Depression and mania are mankind’s oldest known brain disorders and were the first brain disorders conceptualized by Hippocrates as a part of medicine; mania and depression as two parts of the same disease were first described in the first century AD. Yet even today, a diagnosis of bipolar disorder (BD) is often missed in patients who report depressive rather than manic symptoms, and the disorder is still frequently unr
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